Evidence map›Paper›PMID 37496630›Full record

ArticleNanoscale advances2023

HER-2-targeted boron neutron capture therapy using an antibody-conjugated boron nitride nanotube/β-1,3-glucan complex.

Keita Yamana, Riku Kawasaki, Kousuke Kondo, Hidetoshi Hirano, Shogo Kawamura, Yu Sanada, Kaori Bando, Anri Tabata, Hideki Azuma, Takushi Takata and 6 more

Open access · goldAbstract read
In one paragraph

Article in Nanoscale advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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  8. Principles of Biocompatible Nanotube Design for High-Performance Biomaterials.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Keita YamanaProgram of Applied Chemistry, Graduate School of Advanced Science and Engineering 1-4-1 Kagamiyama Higashi-Hiroshima City 739-8527 Japan riku0528@hiroshima-u.ac.jp aikeda@hiroshima-u.ac.jp.
Riku KawasakiProgram of Applied Chemistry, Graduate School of Advanced Science and Engineering 1-4-1 Kagamiyama Higashi-Hiroshima City 739-8527 Japan riku0528@hiroshima-u.ac.jp aikeda@hiroshima-u.ac.jp.ORCID https://orcid.org/0000-0003-1621-8189
Kousuke KondoProgram of Applied Chemistry, Graduate School of Advanced Science and Engineering 1-4-1 Kagamiyama Higashi-Hiroshima City 739-8527 Japan riku0528@hiroshima-u.ac.jp aikeda@hiroshima-u.ac.jp.
Hidetoshi HiranoProgram of Applied Chemistry, Graduate School of Advanced Science and Engineering 1-4-1 Kagamiyama Higashi-Hiroshima City 739-8527 Japan riku0528@hiroshima-u.ac.jp aikeda@hiroshima-u.ac.jp.
Shogo KawamuraProgram of Applied Chemistry, Graduate School of Advanced Science and Engineering 1-4-1 Kagamiyama Higashi-Hiroshima City 739-8527 Japan riku0528@hiroshima-u.ac.jp aikeda@hiroshima-u.ac.jp.
Yu SanadaInstitute for Integrated Radiation and Nuclear Science, Kyoto University 2, Asahiro-Nishi, Kumatori-cho, Sennan-gun Osaka 590-0494 Japan.
Kaori BandoDepartment of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka Metropolitan University 3-3-138 Sugimoto, Sumiyoshi-ku Osaka City 558-8585 Japan.
Anri TabataDepartment of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka Metropolitan University 3-3-138 Sugimoto, Sumiyoshi-ku Osaka City 558-8585 Japan.
Hideki AzumaDepartment of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka Metropolitan University 3-3-138 Sugimoto, Sumiyoshi-ku Osaka City 558-8585 Japan.
Takushi TakataInstitute for Integrated Radiation and Nuclear Science, Kyoto University 2, Asahiro-Nishi, Kumatori-cho, Sennan-gun Osaka 590-0494 Japan.
Yoshinori SakuraiInstitute for Integrated Radiation and Nuclear Science, Kyoto University 2, Asahiro-Nishi, Kumatori-cho, Sennan-gun Osaka 590-0494 Japan.
Hiroki TanakaInstitute for Integrated Radiation and Nuclear Science, Kyoto University 2, Asahiro-Nishi, Kumatori-cho, Sennan-gun Osaka 590-0494 Japan.
Tomoki KodamaProgram of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University 1-3-1 Kagamiyama Higashi-Hiroshima 739-8530 Japan.
Seiji KawamotoProgram of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University 1-3-1 Kagamiyama Higashi-Hiroshima 739-8530 Japan.
Takeshi NagasakiDepartment of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka Metropolitan University 3-3-138 Sugimoto, Sumiyoshi-ku Osaka City 558-8585 Japan.
Atsushi IkedaProgram of Applied Chemistry, Graduate School of Advanced Science and Engineering 1-4-1 Kagamiyama Higashi-Hiroshima City 739-8527 Japan riku0528@hiroshima-u.ac.jp aikeda@hiroshima-u.ac.jp.ORCID https://orcid.org/0000-0003-3492-3455
Kyoto University · JPOsaka Metropolitan University · JPHiroshima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of boron agents with integrated functionality, including biocompatibility, high boron content, and cancer cell targeting, is desired to exploit the therapeutic efficacy of boron neutron capture therapy (BNCT). Here, we report the therapeutic efficacy of BNCT using a HER-2-targeted antibody-conjugated boron nitride nanotube/β-1,3-glucan complex. The anticancer effect of BNCT using our system was 30-fold that of the clinically available boron agent l-BPA/fructose complex.

Identifiers

PMID37496630
PMCPMC10367957
OpenAlexW4379054348

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.