Evidence map›Paper›PMID 37496601›Full record

ArticleOpen forum infectious diseases2023

Longer-term Mortality and Kidney Outcomes of Participants in the Combination Antibiotics for Methicillin-Resistant

Amy Legg, Matthew A Roberts, Jane Davies, Alan Cass, Niamh Meagher, Archana Sud, Vered Daitch, Yael Dishon Benattar, Dafna Yahav, Mical Paul and 28 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Adjunctive β-lactams forTherapeutic advances in infectious disease
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors at 20 institutions in 5 countries.

Amy LeggMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.ORCID https://orcid.org/0000-0001-8228-1536
Matthew A RobertsEastern Health Clinical School, Monash University, Box Hill, Victoria, Australia.
Jane DaviesMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Alan CassMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Niamh MeagherCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Archana SudDepartment of Infectious Diseases, Nepean Hospital and Nepean Clinical School, University of Sydney, Sydney, New South Wales, Australia.
Vered DaitchDepartment of Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel.
Yael Dishon BenattarInfectious Diseases Institute, Rambam Health Care Campus, Haifa, Israel.
Dafna YahavInfectious Diseases Unit, Sheba Medical Centre, Ramat-Gan, Israel.ORCID https://orcid.org/0000-0003-3181-9791
Mical PaulInfectious Diseases Unit, Sheba Medical Centre, Ramat-Gan, Israel.
Chen XinxinNational Centre for Infectious Diseases, Singapore.
Yeo He PingNational Centre for Infectious Diseases, Singapore.
David LyeNational Centre for Infectious Diseases, Singapore.
Russel LeeNational Centre for Infectious Diseases, Singapore.
J Owen RobinsonInfectious Disease Department, Royal Perth Hospital and Fiona Stanley Hospital, PathWest Laboratory Medicine, Perth, Western Australia, Australia.
Hong FooDepartment of Microbiology and Infectious Diseases, NSW Health Pathology, Liverpool, New South Wales, Australia.
Adrian R TramontanaInfectious Diseases Department, Western Health, Footscray, Victoria, Australia.
Narin BakInfectious Diseases Department, The Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Adelaide GrenfellMonash Health, Department of Medicine, Clayton, Victoria, Australia.
Benjamin RogersMonash Infectious Diseases, Monash Health, Monash University School of Clinical Sciences at Monash Health, Clayton, Victoria, Australia.ORCID https://orcid.org/0000-0001-6515-2118
Ying LiCentre for Infectious Diseases and Microbiology, Westmead Hospital, Sydney, New South Wales, Australia.
Neela JoshiCentre for Infectious Diseases and Microbiology, Westmead Hospital, Sydney, New South Wales, Australia.
Matthew O'SullivanDepartment of Infectious Diseases and Microbiology, Westmead Hospital, Sydney, New South Wales, Australia.
Genevieve McKewDepartment of Microbiology and Infectious Diseases, Concord Repatriation and General Hospital, New South Wales Health Pathology, Sydney, NSW, Australia.
Niladri GhoshDepartment of Infectious Diseases, Wollongong Public Hospital, Wollongong, New South Wales, Australia.
Kellie SchneiderImmunology and Infectious Diseases Unit, John Hunter Hospital, Newcastle, New South Wales, Australia.
Natasha E HolmesDepartment of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.
Ravindra DotelDepartment of Infectious Diseases, Blacktown Hospital, Sydney, New South Wales, Australia.
Timothy ChiaDivision of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore.
Sophia ArchuletaLee Kong Chian School of Medicine, Nanyang Technological University, Singapore.ORCID https://orcid.org/0000-0002-8414-6327
Simon SmithDepartment of Medicine, Cairns Hospital, Cairns, Queensland, Australia.
Morgyn S WarnerMicrobiology and Infectious Diseases Directorate, South Australia Pathology, Infectious Diseases Unit, Central Adelaide Local Health Network, Adelaide, South Australia, Australia.
Christina TitinDepartment of Infectious Diseases, Singapore General Hospital, Singapore.
Shirin KalimuddinDepartment of Infectious Diseases, Singapore General Hospital, Singapore.ORCID https://orcid.org/0000-0001-9319-5908
Jason A RobertsFaculty of Medicine, University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0001-6218-435X
Steven Y C TongVictorian Infectious Diseases Service, Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Joshua S DavisMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.ORCID https://orcid.org/0000-0001-9864-5699
Combination Antibiotics for Methicillin-Resistant Staphylococcus aureus (CAMERA2) Study Group
The University of Sydney · AUCharles Darwin University · AUThe University of Melbourne · AUNational University of Singapore · SGThe Royal Melbourne Hospital · AUMonash Health · AUNational Centre for Infectious Diseases · SGNew South Wales Department of Health · AURoyal Adelaide Hospital · AUSouth Australia Pathology · AUBlacktown & Mount Druitt Hospital · AUMurdoch University · AUNanyang Technological University · SGTechnion – Israel Institute of Technology · ILWestmead Hospital · AUWollongong Hospital · AUCairns Hospital · AUEastern Health · AUFootscray Hospital · AUJohn Hunter Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The Combination Antibiotic Therapy for Methicillin-Resistant Methods: Trial sites obtained additional follow-up data. The primary outcome was all-cause mortality, censored at death or the date of last known follow-up. Secondary outcomes included kidney failure or a reduction in kidney function (a 40% reduction in estimated glomerular filtration rate to <60 mL/minute/1.73 m Results: This post hoc analysis included extended follow-up data for 260 patients. Overall, 123 of 260 (47%) of participants died, with a median population survival estimate of 3.4 years (235 deaths per 1000 person-years). Fifty-five patients died within 90 days after CAMERA2 trial randomization; another 68 deaths occurred after day 90. Using univariable Cox proportional hazards regression, mortality was not associated with either the assigned treatment arm in CAMERA2 (hazard ratio [HR], 0.84 [95% confidence interval [CI], .59-1.19]; Conclusions: In this cohort of patients hospitalized with methicillin-resistant

Indexed as

acute kidney injurynephrotoxicityStaphylococcus aureus bacteremia

Identifiers

PMID37496601
PMCPMC10368200
OpenAlexW4383058267

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.