Evidence map›Paper›PMID 37496314›Full record

ArticleProteomics2023

Physiology of trans-translation deficiency in Bacillus subtilis - a comparative proteomics study.

Melissa Vázquez-Hernández, Stephanie L Leedom, Kenneth C Keiler, Julia Elisabeth Bandow

Open access · hybridAbstract read
In one paragraph

Article in Proteomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Cooperative and Independent Functionality of tmRNA and SmpB inInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Melissa Vázquez-HernándezApplied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.ORCID 0000-0003-2527-9135
Stephanie L LeedomDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.
Kenneth C KeilerDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.
Julia Elisabeth BandowApplied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.ORCID 0000-0003-4100-8829
Pennsylvania State University · USRuhr University Bochum · DE

Funding

Physiology of ribosome rescue in bacteriaR01GM121650 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI KEILER, KENNETH C · 2017 to 2025
$3.8M
NIGMS NIH HHS R01 GM121650
6 · The paper itself

Abstract

trans-Translation is the most effective ribosome rescue system known in bacteria. While it is essential in some bacteria, Bacillus subtilis possesses two additional alternative ribosome rescue mechanisms that require the proteins BrfA or RqcH. To investigate the physiology of trans-translation deficiency in the model organism B. subtilis, we compared the proteomes of B. subtilis 168 and a ΔssrA mutant in the mid-log phase using gel-free label-free quantitative proteomics. In chemically defined medium, the growth rate of the ssrA deletion mutant was 20% lower than that of B. subtilis 168. An

Indexed as

Bacillus subtilisBacterial ProteinsProtein BiosynthesisProteomeProteomicsRibosomal ProteinsBacterial ProteinsProteomeRibosomal Proteinsbacteriagene regulationLC-MSEproteometranslation

Identifiers

PMID37496314
PMCPMC11426337
OpenAlexW4385294574

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.