Evidence map›Paper›PMID 37496069›Full record

SynthesisWorld journal of surgical oncology2023

Clinical significance of matrix metalloproteinase-9 expression in papillary thyroid carcinoma: a meta-analysis.

Jinxu Wen, Xiaoru Qin, Jiayi Zhang, Xiaoyong Wu, Xuemin Yan, Kewen Lu, Pei Yang, Shuaichong Ji, Xiangdong Zhao, Yuexin Wang

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in World journal of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jinxu WenHebei Medical University, Shijiazhuang, 050051, Hebei Province, China.
Xiaoru QinDepartment of Thyroid and Breast Surgery, Hebei General Hospital, Shijiazhuang, 050051, Hebei Province, China.
Jiayi ZhangNorth China University of Science and Technology, Tangshan, 063000, Hebei Province, China.
Xiaoyong WuNorth China University of Science and Technology, Tangshan, 063000, Hebei Province, China.
Xuemin YanNorth China University of Science and Technology, Tangshan, 063000, Hebei Province, China.
Kewen LuHebei Medical University, Shijiazhuang, 050051, Hebei Province, China.
Pei YangHebei Medical University, Shijiazhuang, 050051, Hebei Province, China.
Shuaichong JiNorth China University of Science and Technology, Tangshan, 063000, Hebei Province, China.
Xiangdong ZhaoNorth China University of Science and Technology, Tangshan, 063000, Hebei Province, China.
Yuexin WangDepartment of Thyroid and Breast Surgery, Hebei General Hospital, Shijiazhuang, 050051, Hebei Province, China. wangyx886@sina.com.
North China University of Science and Technology · CNHebei Medical University · CNHebei General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of this study was to investigate the relationship between the expression of matrix metalloproteinase-9 (MMP-9) and pathological indexes in papillary thyroid carcinoma (PTC). EVIDENCE OBTAINED: The database was searched in PubMed, Embase, CNKI, and Web of Science databases for relevant clinical trials. The odds ratio (OR) and 95% confidence interval (CI) show the effect of MMP-9 expression and age, tumour size, gender, lymph node metastasis (LNM), and TNM (tumour, lymph node, metastasis) stage. Statistical analysis of the data was performed using Stata 17.0. EVIDENCE SYNTHESIS: A total of 1433 patients with PTC were included in this meta-analysis. MMP-9 expression was significantly correlated with LNM (OR = 3.92, 95% CI = 2.71-5.65, P = 0.000), tumour size (OR = 1.69, 95% CI = 1.13-2.52, P = 0.011), and TNM stage (OR = 2.95, 95% CI = 2.10-4.13, P = 0.000), but not with gender (OR = 0.90, 95% CI = 0.66-1.22, P = 0.487) and age (OR = 1.36, 95% CI = 0.93-1.98, P = 0.115).

conclusionsOur meta-analysis showed that MMP-9 was significantly associated with LNM, tumour size, and TNM stage; therefore, MMP-9 may be a reliable prognostic biomarker for patients with PTC. However, more high-quality studies are needed to support these findings further.

Indexed as

Thyroid NeoplasmsClinical RelevanceHumansLymphatic MetastasisMatrix Metalloproteinase 9Thyroid Cancer, PapillaryMatrix Metalloproteinase 9MMP9 protein, humanBiomarkerImmunohistochemistryMatrix metalloproteinase-9Papillary thyroid carcinoma

Identifiers

PMID37496069
PMCPMC10369753
OpenAlexW4385281518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.