Evidence map›Paper›PMID 37495763›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2023

Pharmacological and metabolic parameters of [

Braeden A Mair, Jason G E Zelt, Kirabo Nekesa, Zacharie Saint-Georges, Katie Dinelle, Myriam Adi, Simon Robinson, Lisa M Mielniczuk, Jakov Shlik, Rob S Beanlands and 2 more

Abstract read
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In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Braeden A MairDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada.
Jason G E ZeltUniversity of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
Kirabo NekesaDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada.
Zacharie Saint-GeorgesUniversity of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
Katie DinelleThe University of Ottawa Institute of Mental Health Research at the Royal, Ottawa, Canada.
Myriam AdiDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada.
Simon RobinsonLantheus Medical Imaging, Inc, North Billerica, MA, USA.
Lisa M MielniczukUniversity of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
Jakov ShlikThe University of Ottawa Institute of Mental Health Research at the Royal, Ottawa, Canada.
Rob S BeanlandsUniversity of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
Robert A deKempUniversity of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada. radekemp@ottawaheart.ca.
Benjamin H RotsteinDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada. benjamin.rotstein@uottawa.ca.
University of Ottawa · CARoyal Ottawa Mental Health Centre · CALantheus Medical Imaging (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiac sympathetic nervous system molecular imaging has demonstrated prognostic value. Compared with meta-[

methodsBlood sampling was performed on 20 participants concurrent to FBBG PET imaging (healthy = NORM, non-ischemic cardiomyopathy = NICM, ischemic cardiomyopathy = ICM, post-traumatic stress disorder = PTSD). Image-derived blood time-activity curves were transformed to plasma input functions using cohort-specific corrections for plasma protein binding, plasma-to-whole blood distribution, and metabolism.

resultsThe plasma-to-whole blood ratio was 0.78 ± 0.06 for NORM, 0.64 ± 0.06 for PTSD and 0.60 ± 0.14 for (N)ICM after 20 minutes. 22 ± 4% of FBBG was bound to plasma proteins. Metabolism of FBBG in (N)ICM was delayed, with a parent fraction of 0.71 ± 0.05 at 10 minutes post-injection compared to 0.53 ± 0.03 for PTSD/NORM. While there were variations in metabolic rate, metabolite-corrected plasma input functions were similar across all cohorts.

conclusionsRapid plasma clearance of FBBG limits the impact of disease-specific corrections of the blood input function for tracer kinetic modeling.

Indexed as

CardiomyopathiesGuanidinesFluorobenzenesHeartHumansPositron-Emission TomographyflubrobenguaneFluorobenzenesGuanidinesFlubrobenguanefluorine-18metabolismPETsympathetic nervous system

Identifiers

PMID37495763
OpenAlexW4385285621

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.