Evidence map›Paper›PMID 37495698›Full record

ArticleNature2023

Small protein modules dictate prophage fates during polylysogeny.

Justin E Silpe, Olivia P Duddy, Grace E Johnson, Grace A Beggs, Fatima A Hussain, Kevin J Forsberg, Bonnie L Bassler

Abstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Revisiting the life cycle of temperate phages.Nature reviews. Microbiology · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Human gut strains ofApplied and environmental microbiology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Bacterial peptide deformylase inhibitors induce prophages in competitors.bioRxiv : the preprint server for biology · 2025
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Justin E SilpeDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-6264-8553
Olivia P DuddyDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Grace E JohnsonDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Grace A BeggsDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.ORCID 0000-0003-3537-913X
Fatima A HussainDepartment of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-8926-3875
Kevin J ForsbergDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-1545-8925
Bonnie L BasslerDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA. bbassler@princeton.edu.ORCID 0000-0002-0043-746X

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4M
Intra- and Inter- Species Communication in BacteriaR37GM065859 · NIGMS · PRINCETON UNIVERSITY · PI BASSLER, BONNIE L · 2016 to 2025
$3.4M
Discovery of bacterial defense and phage counter-defense strategiesDP2AI154402 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI FORSBERG, KEVIN J · 2021 to 2025
$2.6M
Quorum-sensing mediated communication between pandemic Vibrio cholerae and phage VP882F32GM149034 · NIGMS · PRINCETON UNIVERSITY · PI BEGGS, GRACE · 2023 to 2024
$143k
NIAID NIH HHS DP2 AI154402NIGMS NIH HHS F32 GM149034NIGMS NIH HHS R37 GM065859NIGMS NIH HHS T32 GM007388
6 · The paper itself

Abstract

Most bacteria in the biosphere are predicted to be polylysogens harbouring multiple prophages

Indexed as

BacteriaBacteriophagesLysogenyProphagesViral ProteinsDNA DamageDNA, ViralHost-Pathogen InteractionsSingle-Cell AnalysisTranscription FactorsVirus ActivationDNA, ViralTranscription FactorsViral Proteins

Identifiers

PMID37495698
PMCPMC10432266

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.