Evidence map›Paper›PMID 37495694›Full record

ArticleNature2023

Evolutionarily divergent mTOR remodels translatome for tissue regeneration.

Olena Zhulyn, Hannah D Rosenblatt, Leila Shokat, Shizhong Dai, Duygu Kuzuoglu-Öztürk, Zijian Zhang, Davide Ruggero, Kevan M Shokat, Maria Barna

Open access · greenAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Signal control during tissue regeneration in adult animals.Nature reviews. Molecular cell biology · 2026
    Review
  6. Article
  7. Metabolic changes during cardiac regeneration in the axolotl.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. mRNA translational control of regeneration.Current opinion in genetics & development · 2025
    Review
  18. Article
  19. Article
  20. MgScience advances · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Olena ZhulynDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Hannah D RosenblattDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Leila ShokatDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Shizhong DaiDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA.
Duygu Kuzuoglu-ÖztürkDepartment of Urology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-1737-5020
Zijian ZhangDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Davide RuggeroDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA.ORCID 0000-0002-9444-5865
Kevan M ShokatDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA.ORCID 0000-0001-8590-7741
Maria BarnaDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA. mbarna@stanford.edu.ORCID 0000-0002-6843-4396
Stanford University · USUniversity of California, San Francisco · USHoward Hughes Medical Institute · USSickKids Foundation · CA

Funding

GENETICS TRAINING PROGRAM FOR PHD CANDIDATEST32GM007790 · NIGMS · STANFORD UNIVERSITY · PI BRUNET, ANNE, KINGSLEY, DAVID M · 1985 to 2020
$12.8M
Specialized Translational Control of Stem Cell Differentiation and Embryonic DevelopmentR01HD086634 · NICHD · STANFORD UNIVERSITY · PI BARNA, MARIA · 2016 to 2025
$5.5M
Research Training in Chemistry and Chemical BiologyT32GM145460 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jason E Gestwicki · 2022 to 2026
$3.1M
Rapid remodeling of the translatome underlying wound healing and regenerationR01HD105731 · NICHD · STANFORD UNIVERSITY · PI Maria Barna · 2022 to 2026
$1.7M
Ribosomes and Regeneration: Defining the Role of Protein Synthesis in Tissue Development, Homeostasis and Repair.K99HD099787 · NICHD · STANFORD UNIVERSITY · PI ZHULYN, OLENA · 2019 to 2021
$271k
NICHD NIH HHS K99 HD099787NICHD NIH HHS R01 HD086634NICHD NIH HHS R01 HD105731NIGMS NIH HHS T32 GM007790NIGMS NIH HHS T32 GM145460
6 · The paper itself

Abstract

An outstanding mystery in biology is why some species, such as the axolotl, can regenerate tissues whereas mammals cannot

Indexed as

Ambystoma mexicanumBiological EvolutionProtein BiosynthesisRegenerationTOR Serine-Threonine KinasesAmino Acid SequenceAnimalsAntioxidantsExtremitiesHumansMechanistic Target of Rapamycin Complex 1MiceNutrientsPolyribosomesRNA, MessengerSpecies SpecificityAntioxidantsMechanistic Target of Rapamycin Complex 1NutrientsRNA, MessengerTOR Serine-Threonine Kinases

Identifiers

PMID37495694
PMCPMC11181899
OpenAlexW4385271083

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.