Evidence map›Paper›PMID 37495693›Full record

ArticleNature2023

Structure of an endogenous mycobacterial MCE lipid transporter.

James Chen, Alice Fruhauf, Catherine Fan, Jackeline Ponce, Beatrix Ueberheide, Gira Bhabha, Damian C Ekiert

Open access · greenAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Mce transport systems inJournal of bacteriology · 2026
    Review
  3. Article
  4. Interactions at theMicrobiology (Reading, England) · 2026
    Review
  5. Deciphering the different Mycobacterium avium complex infections of HIV and non-HIV patients by bacterial GWAS and immune cells flow cytometry.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Structural elucidation of the hexameric MmpS4-MmpL4 complex frombioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Structural and functional analysis of theProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Article
  19. Genetic determinants ofMicrobiology spectrum · 2025
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

James ChenDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.ORCID 0000-0002-2311-003X
Alice FruhaufDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.ORCID 0000-0002-1366-5410
Catherine FanDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.ORCID 0000-0001-6112-6510
Jackeline PonceProteomics Laboratory, Division of Advanced Research Technologies, New York University School of Medicine, New York, NY, USA.
Beatrix UeberheideProteomics Laboratory, Division of Advanced Research Technologies, New York University School of Medicine, New York, NY, USA.
Gira BhabhaDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA. gira.bhabha@gmail.com.ORCID 0000-0003-0624-6178
Damian C EkiertDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA. damian.ekiert@ekiertlab.org.ORCID 0000-0002-2570-0404
New York University · USMédecins Sans Frontières · US

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1M
Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
Structural characterization of MCE transport systems from Mycobacterium tuberculosisR01AI174646 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Gira Bhabha, Damian Ekiert · 2023 to 2026
$3.1M
Acquisition of an Orbitrap Elite Mass Spectrometer with ETDS10OD010582 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI UEBERHEIDE, BEATRIX MAGDALENA · 2013 to 2013
$600k
NCI NIH HHS P30 CA016087NIAID NIH HHS R01 AI174646NIGMS NIH HHS U24 GM129547NIH HHS S10 OD010582
6 · The paper itself

Abstract

To replicate inside macrophages and cause tuberculosis, Mycobacterium tuberculosis must scavenge a variety of nutrients from the host

Indexed as

Bacterial ProteinsCryoelectron MicroscopyLipidsMembrane Transport ProteinsMycobacterium tuberculosisVirus InternalizationAnimalsATP-Binding Cassette TransportersHydrophobic and Hydrophilic InteractionsMultiprotein ComplexesPeriplasmProtein DomainsTuberculosisVirulence FactorsATP-Binding Cassette TransportersBacterial ProteinsLipidsMembrane Transport ProteinsMultiprotein ComplexesVirulence Factors

Identifiers

PMID37495693
PMCPMC12817965
OpenAlexW4385289080

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.