Evidence map›Paper›PMID 37495692›Full record

ArticleNature2023

Sub-1.4 cm

M E Inda-Webb, M Jimenez, Q Liu, N V Phan, J Ahn, C Steiger, A Wentworth, A Riaz, T Zirtiloglu, K Wong and 14 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Programming Next-Generation Synthetic Biosensors by Genetic Circuit Design.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  14. Article
  15. Article
  16. Probiotic-Based Materials as Living Therapeutics.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

M E Inda-Webb *Synthetic Biology Group, MIT Synthetic Biology Center, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-3840-7370
M Jimenez *Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-4211-1852
Q LiuElectrical and Computer Engineering Department, Boston University, Boston, MA, USA.ORCID 0000-0001-7852-9092
N V PhanThe Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-6849-4519
J AhnThe Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
C SteigerDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
A WentworthDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
A RiazElectrical and Computer Engineering Department, Boston University, Boston, MA, USA.
T ZirtilogluElectrical and Computer Engineering Department, Boston University, Boston, MA, USA.
K WongDivision of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
K IshidaDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
N FabianDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
J JenkinsDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-7698-9888
J KuosmanenDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
W MadaniDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
R McNallyDivision of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Y LaiSynthetic Biology Group, MIT Synthetic Biology Center, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
A HaywardDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
M MimeeDepartment of Microbiology, Biological Sciences Division and Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, USA.ORCID 0000-0002-3083-2671
P NadeauAnalog Devices, Boston, MA, USA.ORCID 0000-0002-7820-1625
A P ChandrakasanDepartment of Electrical Engineering and Computer Science, MIT, Cambridge, MA, USA.ORCID 0000-0002-5977-2748
G TraversoDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. cgt20@mit.edu.ORCID 0000-0001-7851-4077
R T YazicigilElectrical and Computer Engineering Department, Boston University, Boston, MA, USA. rty@bu.edu.ORCID 0000-0002-1492-2941
T K LuSynthetic Biology Group, MIT Synthetic Biology Center, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. timlu@mit.edu.ORCID 0000-0002-3918-8923

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transient molecules in the gastrointestinal tract such as nitric oxide and hydrogen sulfide are key signals and mediators of inflammation. Owing to their highly reactive nature and extremely short lifetime in the body, these molecules are difficult to detect. Here we develop a miniaturized device that integrates genetically engineered probiotic biosensors with a custom-designed photodetector and readout chip to track these molecules in the gastrointestinal tract. Leveraging the molecular specificity of living sensors

Indexed as

BiomarkersBiosensing TechniquesHydrogen SulfideInflammationNitric OxideAdministration, OralAnimalsBacteriaBody SizeCapsulesDisease ProgressionGastrointestinal TractHumansInflammatory Bowel DiseasesLuminescenceModels, AnimalBiomarkersCapsulesHydrogen SulfideNitric Oxide

Identifiers

PMID37495692

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.