ArticleNature2023
Rewiring cancer drivers to activate apoptosis.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 93 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 1 pooled it
23.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
93 citing papers in PubMed, 1 synthesis or guideline pooled it, 152 citations in OpenAlex.
- Global research prospects and trends in TFH cells and tumors: a bibliometric analysis.Frontiers in oncology · 2025Pooled it
- A Versatile DNA-Encoded Library Platform for the Discovery of Highly Cooperative Chemical Inducers of Proximity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cell type-selective targeting by heterobifunctional protein binders via in-cell enrichment.Nature communications · 2026Article
- A bivalent molecular glue linking lysine acetyltransferases to oncogene-induced cell death.Cell · 2026Article
- A pharmacological modality to sequester homomeric proteins.Nature chemical biology · 2026Article
- Targeting CDKs in the RNAPII transcription cycle.Nature reviews. Drug discovery · 2026Review
- The roles of chromatin remodeling and 3D genome organization in cancers: from mechanistic insights to emerging treatment options.Molecular cancer · 2026Review
- Proteomics-Driven Strategies for Proximity-Inducing Drug Discovery.Angewandte Chemie (International ed. in English) · 2026Review
- FDA Approval of the First-Ever PROTAC: Vepdegestrant (ARV-471) Marks a New Era in Targeted Protein Degradation.Journal of medicinal chemistry · 2026Article
- Targeted Transcriptional Repression by Induced Proximity.ACS central science · 2026Article
- Induced ubiquitination of the partially disordered estrogen receptor alpha via a 14-3-3 directed molecular glue-PROTAC.Nature communications · 2026Article
- Eyes Toward the Clinic: Selective Inhibition and Degradation Approaches to Bromodomain-Containing Proteins.Chembiochem : a European journal of chemical biology · 2026Review
- TBL1XR1 mutations promoted tumor progression in diffuse large B-cell lymphoma through impairing nature killer cytotoxicity via the MYC-CD47/PD-L1 axis.Molecular cancer · 2026Article
- Deciphering programmed cell death for gastric cancer prognosis: AKR1B1 as a key player.Journal of applied genetics · 2026Article
- Activating p53Nature communications · 2026Article
- Branching beyond bifunctional linkers: synthesis of macrocyclic and trivalent PROTACs.Nature protocols · 2026Review
- Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs.Nature chemical biology · 2026Article
- Rewiring Oncogenic Transcriptional Complexes with Domain-ALTeration Chimeras (DALTACs) in Prostate Cancer.bioRxiv : the preprint server for biology · 2026Article
- Biophysical Modeling Elucidates Mechanistic Principles for Rational Molecular Glue Design.Journal of chemical information and modeling · 2026Article
- Discovery of molecular glues that bind FKBP12 and structurally distinct targets using DNA-encoded libraries.Nature communications · 2026Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
15 authors at 3 institutions in 1 country.
Sai Gourisankar *Department of Pathology, Stanford University, Stanford, CA, USA.
Andrey Krokhotin *Department of Pathology, Stanford University, Stanford, CA, USA.
Wenzhi Ji *Department of Chemical and Systems Biology, Stanford Cancer Institute, ChEM-H, Stanford University, Stanford, CA, USA.
Xiaofan LiuDepartment of Chemical and Systems Biology, Stanford Cancer Institute, ChEM-H, Stanford University, Stanford, CA, USA.
Chiung-Ying ChangDepartment of Pathology, Stanford University, Stanford, CA, USA.
Samuel H KimDepartment of Pathology, Stanford University, Stanford, CA, USA.
Zhengnian LiDepartment of Chemical and Systems Biology, Stanford Cancer Institute, ChEM-H, Stanford University, Stanford, CA, USA.
Wendy WenderskiDepartment of Pathology, Stanford University, Stanford, CA, USA.
Juste M SimanauskaiteDepartment of Pathology, Stanford University, Stanford, CA, USA.
Haopeng YangDepartment of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hannes VogelDepartment of Pathology, Stanford University, Stanford, CA, USA.
Tinghu ZhangDepartment of Chemical and Systems Biology, Stanford Cancer Institute, ChEM-H, Stanford University, Stanford, CA, USA.
Michael R GreenDepartment of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-6309-9472
Nathanael S GrayDepartment of Chemical and Systems Biology, Stanford Cancer Institute, ChEM-H, Stanford University, Stanford, CA, USA. nsgray01@stanford.edu.ORCID 0000-0001-5354-7403
Gerald R CrabtreeDepartment of Pathology, Stanford University, Stanford, CA, USA. crabtree@stanford.edu.ORCID 0000-0001-9685-7911
Stanford University · USThe University of Texas MD Anderson Cancer Center · USCardiovascular Institute of the South · US
Funding
Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Melinda L. Telli · 2007 to 2026
$71.4MATP-Dependent Chromatin Remodeling in Human MalignancyR01CA163915 · NCI · STANFORD UNIVERSITY · PI Gerald R. Crabtree · 2012 to 2026
$5.4MATP-Dependent Chromatin Regulation in Neurodevelopment and Human DiseaseR37NS046789 · NINDS · STANFORD UNIVERSITY · PI CRABTREE, GERALD R. · 2013 to 2019
$2.7MHIJACKING CANCER DRIVERS TO ACTIVATE PROAPOPTOTIC GENES IN DLBCLR01CA276167 · NCI · STANFORD UNIVERSITY · PI Gerald R. Crabtree, NATHANAEL Schiander GRAY · 2023 to 2026
$2.2MSmall molecule regulation of endogenous transcription factors for circuit-specific neuromodulationRF1MH126720 · NIMH · STANFORD UNIVERSITY · PI CRABTREE, GERALD R. · 2021 to 2021
$1.3MSciex 6500+ QTrap Mass SpectrometerS10OD030332 · OD · SCRIPPS FLORIDA · PI CAMERON, MICHAEL DARIN · 2021 to 2021
$486kChemical-inducible Epigenome Editors for Allele-specific Gene Regulation in Developmental DisordersF31HD103339 · NICHD · STANFORD UNIVERSITY · PI GOURISANKAR, SAI · 2020 to 2022
$124kMutations in ACTL6B cause recessive autism: affected families, mouse model, molecular and circuit mechanismsF99NS118735 · NINDS · STANFORD UNIVERSITY · PI WENDERSKI, WENDY · 2020 to 2021
$54kNCI NIH HHS P30 CA124435NCI NIH HHS R01 CA163915NCI NIH HHS R01 CA276167NICHD NIH HHS F31 HD103339NIH HHS S10 OD030332NIMH NIH HHS RF1 MH126720NINDS NIH HHS F99 NS118735NINDS NIH HHS R37 NS046789
Abstract
Genes that drive the proliferation, survival, invasion and metastasis of malignant cells have been identified for many human cancers
Indexed as
ApoptosisGene Expression Regulation, NeoplasticLymphoma, Large B-Cell, DiffuseTranscription FactorsBromodomain Containing ProteinsCarcinogenesisCell Cycle ProteinsEpigenesis, GeneticHumansPromoter Regions, GeneticProto-Oncogene Proteins c-bcl-6Tumor Suppressor Protein p53BCL6 protein, humanBRD4 protein, humanBromodomain Containing ProteinsCell Cycle ProteinsProto-Oncogene Proteins c-bcl-6TP53 protein, humanTranscription FactorsTumor Suppressor Protein p53
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.