ArticleNature communications2023
Rapid genetic screening with high quality factor metasurfaces.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Finite-Size Effects in Nonlocal Metasurfaces.ACS photonics · 2026Article
- A Dual-Channel Synergistic Ultrasensitive Biosensor for Tumor Liquid Biopsy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Wafer-Scale All-Dielectric Quasi-BIC Metasurfaces: Bridging High-Throughput Deep-UV Lithography with Nanophotonic Applications.Nano letters · 2026Article
- High-efficiency active membrane metasurfaces.Science advances · 2025Article
- All dielectric etalon based metasurfaces optimized for high FOM refractive index sensing.Scientific reports · 2025Article
- Unlocking the Translational Potential of Nanophotonic Biosensors: Perspectives on Application-Guided Design.ACS photonics · 2025Review
- Antibiotic-Mediated Plasmonic-Mie Resonance for Biosensing Applications on a Novel Silicon Nanopillar Metasurface.Advanced materials interfaces · 2025Article
- Plasmonic coffee-ring biosensing for AI-assisted point-of-care diagnostics.Nature communications · 2025Article
- Nanophotonic sensing and label-free imaging of extracellular vesicles.Light, science & applications · 2025Review
- Free-space high-Q nanophotonics.Light, science & applications · 2025Review
- Leveraging Optical Anisotropy of the Morpho Butterfly Wing for Quantitative, Stain-Free, and Contact-Free Assessment of Biological Tissue Microstructures.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Deep-Ultraviolet AlN Metalens with Imaging and Ultrafast Laser Microfabrication Applications.Nano letters · 2025Article
- Enhanced biochemical sensing with high-Q transmission resonances in free-standing membrane metasurfaces.Optica · 2025Article
- High-throughput antibody screening with high-quality factor nanophotonics and bioprinting.ArXiv · 2024Article
- Trapping light in air with membrane metasurfaces for vibrational strong coupling.Nature communications · 2024Article
- Very-large-scale-integrated high quality factor nanoantenna pixels.Nature nanotechnology · 2024Article
- Weak-cooperative binding of a long single-stranded DNA chain on a surface.Nucleic acids research · 2024Article
- The rise of electrically tunable metasurfaces.Science advances · 2024Review
- Topology Optimization Enables High-Nano letters · 2024Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Genetic analysis methods are foundational to advancing personalized medicine, accelerating disease diagnostics, and monitoring the health of organisms and ecosystems. Current nucleic acid technologies such as polymerase chain reaction (PCR) and next-generation sequencing (NGS) rely on sample amplification and can suffer from inhibition. Here, we introduce a label-free genetic screening platform based on high quality (high-Q) factor silicon nanoantennas functionalized with nucleic acid fragments. Each high-Q nanoantenna exhibits average resonant quality factors of 2,200 in physiological buffer. We quantitatively detect two gene fragments, SARS-CoV-2 envelope (E) and open reading frame 1b (ORF1b), with high-specificity via DNA hybridization. We also demonstrate femtomolar sensitivity in buffer and nanomolar sensitivity in spiked nasopharyngeal eluates within 5 minutes. Nanoantennas are patterned at densities of 160,000 devices per cm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.