Evidence map›Paper›PMID 37495580›Full record

ArticleNature communications2023

Achieving tissue-level softness on stretchable electronics through a generalizable soft interlayer design.

Yang Li, Nan Li, Wei Liu, Aleksander Prominski, Seounghun Kang, Yahao Dai, Youdi Liu, Huawei Hu, Shinya Wai, Shilei Dai and 8 more

Abstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Article
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  10. Article
  11. Reprogrammable Phase-Transition Composites for Adaptive Dynamic Shape Morphing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  12. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  13. Article
  14. Article
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yang LiPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.ORCID 0000-0003-1912-1438
Nan LiPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.
Wei LiuPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.ORCID 0000-0002-1207-204X
Aleksander ProminskiDepartment of Chemistry, The University of Chicago, Chicago, IL, 60637, USA.
Seounghun KangPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.
Yahao DaiPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.
Youdi LiuPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.
Huawei HuPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.ORCID 0000-0002-9790-8837
Shinya WaiPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.
Shilei DaiPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.ORCID 0000-0002-5849-0503
Zhe ChengDepartment of Chemistry, The University of Chicago, Chicago, IL, 60637, USA.
Qi SuPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.
Ping ChengPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.
Chen WeiDepartment of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Lihua JinDepartment of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0000-0001-7812-9056
Jeffrey A HubbellPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.ORCID 0000-0003-0276-5456
Bozhi TianDepartment of Chemistry, The University of Chicago, Chicago, IL, 60637, USA.ORCID 0000-0003-0593-0023
Sihong WangPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA. sihongwang@uchicago.edu.ORCID 0000-0002-3611-0004

Funding

Immunocompatible electronic polymers and devices for implantable sensors and stimulators that resist foreign-body responsesDP2EB034563 · NIBIB · UNIVERSITY OF CHICAGO · PI WANG, SIHONG · 2022 to 2025
$2.3M
NIBIB NIH HHS DP2 EB034563
6 · The paper itself

Abstract

Soft and stretchable electronics have emerged as highly promising tools for biomedical diagnosis and biological studies, as they interface intimately with the human body and other biological systems. Most stretchable electronic materials and devices, however, still have Young's moduli orders of magnitude higher than soft bio-tissues, which limit their conformability and long-term biocompatibility. Here, we present a design strategy of soft interlayer for allowing the use of existing stretchable materials of relatively high moduli to versatilely realize stretchable devices with ultralow tissue-level moduli. We have demonstrated stretchable transistor arrays and active-matrix circuits with moduli below 10 kPa-over two orders of magnitude lower than the current state of the art. Benefiting from the increased conformability to irregular and dynamic surfaces, the ultrasoft device created with the soft interlayer design realizes electrophysiological recording on an isolated heart with high adaptability, spatial stability, and minimal influence on ventricle pressure. In vivo biocompatibility tests also demonstrate the benefit of suppressing foreign-body responses for long-term implantation. With its general applicability to diverse materials and devices, this soft-interlayer design overcomes the material-level limitation for imparting tissue-level softness to a variety of bioelectronic devices.

Indexed as

Wearable Electronic DevicesElastic ModulusElectronicsHumans

Identifiers

PMID37495580
PMCPMC10372055

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.