ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023
Abstraction of Reward Context Facilitates Relative Reward Coding in Neural Populations of the Macaque Anterior Cingulate Cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 15 citations in OpenAlex.
- Compression as a neural mechanism of mnemonic chunking in prefrontal cortex.Current biology : CB · 2026Article
- Compressive learning scaffolds higher-order network structure to enhance human knowledge acquisition.Nature communications · 2026Article
- Differential Coding of Associative Memory Information in the Macaque Lateral Prefrontal Cortex and Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Decodanda: a Python toolbox for best-practice decoding and geometric analysis of neural representations.bioRxiv : the preprint server for biology · 2026Article
- Bridging neurobiological mechanisms and translational applications in cognitive science: inspirations from the MCCS-NYUAD meeting 2025.Molecular brain · 2026Review
- Neural representations of beliefs in a multi-dimensional inference task.bioRxiv : the preprint server for biology · 2026Article
- Neural representation of the decisional reference point in monkeys.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dopamine and serotonin transients predict depressive symptom relief following deep brain stimulation of human subcallosal cingulate cortex.bioRxiv : the preprint server for biology · 2025Article
- Single-Neuron Encoding of Learnability in the Dorsal Anterior Cingulate Cortex.bioRxiv : the preprint server for biology · 2025Article
- Efficient and dynamic neural geometry of value and modality encoding in the primate putamen for value-guided behavior.Nature communications · 2025Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
The anterior cingulate cortex (ACC) is believed to be involved in many cognitive processes, including linking goals to actions and tracking decision-relevant contextual information. ACC neurons robustly encode expected outcomes, but how this relates to putative functions of ACC remains unknown. Here, we approach this question from the perspective of population codes by analyzing neural spiking data in the ventral and dorsal banks of the ACC in two male monkeys trained to perform a stimulus-motor mapping task to earn rewards or avoid losses. We found that neural populations favor a low dimensional representational geometry that emphasizes the valence of potential outcomes while also facilitating the independent, abstract representation of multiple task-relevant variables. Valence encoding persisted throughout the trial, and realized outcomes were primarily encoded in a relative sense, such that cue valence acted as a context for outcome encoding. This suggests that the population coding we observe could be a mechanism that allows feedback to be interpreted in a context-dependent manner. Together, our results point to a prominent role for ACC in context setting and relative interpretation of outcomes, facilitated by abstract, or untangled, representations of task variables.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.