ArticleInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group2023
Transcranial histotripsy parameter study in primary and metastatic murine brain tumor models.
Article in International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 18 citations in OpenAlex.
- Focused ultrasound for brain metastases.Neuro-oncology advances · 2026Review
- Focused ultrasound for enhancing cell-based immunotherapies in neuro-oncology.Neuro-oncology advances · 2026Review
- Applications of transcranial focused ultrasound for primary brain tumors.Neuro-oncology advances · 2026Review
- Histotripsy dose impacts tumor cellular damage and treatment outcomes in a preclinical model of hepatocellular carcinoma.Scientific reports · 2026Article
- Article
- Histotripsy treatment reduces tumor burden and extends survival in an orthotopic mouse model of osteosarcoma.Frontiers in oncology · 2026Article
- Prospects for clinical translation of histotripsy in liver applications: a systematic review based on preclinical studies.Quantitative imaging in medicine and surgery · 2026Review
- Review
- Review
- Simulation Study on the Effect of HIFU Irradiation Frequency and Duty Cycle Combination Parameter Optimization on Thermal Lesion of Biological Tissue.Journal of biomedical physics & engineering · 2025Article
- MR-Cavitation Dynamics Encoded (MR-CaDE) imaging.Magnetic resonance in medicine · 2025Article
- High-Resolution Ultrasound Data for AI-Based Segmentation in Mouse Brain Tumor.Scientific data · 2025Article
- A pre-clinical MRI-guided all-in-one focused ultrasound system for murine brain studies.Scientific reports · 2025Article
- Assessment of histotripsy as a bone-sparing tumor ablation technique inFrontiers in veterinary science · 2025Article
- Innovative Approaches to Brain Cancer: The Use of Magnetic Resonance-guided Focused Ultrasound in Glioma Therapy.Cancers · 2024Review
- Advances in Tumor Management: Harnessing the Potential of Histotripsy.Radiology. Imaging cancer · 2024Review
- Characterization of Blood-Brain Barrier Opening Induced by Transcranial Histotripsy in Murine Brains.Ultrasound in medicine & biology · 2024Article
- Insights fromInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2024Review
- Effect of focused ultrasound-induced mechanical ablation on stemness and dormancy properties of residual/peri-focally localized glioblastoma cells.Neuro-oncology advancesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThis study investigated the effect of various histotripsy dosages on tumor cell kill and associated bleeding in two murine brain tumor models (glioma [Gl261] and lung metastasis [LL/2-Luc2]). METHODS AND MATERIALS: GL261 or LL/2-Luc2 cells were cultured and implanted into the brains of C57BL/6 mice. Histotripsy (1-cycle pulses, 5 Hz PRF, 30 MPa-P) was performed using a 1 MHz transducer for five different dosages for each cell line: 5, 20 or 200 pulses per location (PPL) at a single treatment point, or 5 or 10-20 PPL at multiple treatment points. MRI, bioluminescence imaging and histology were used to assess tumor ablation and treatment effects within 4-6 h post-treatment.
resultsAll treatment groups resulted in a reduction of BLI intensity for the LL/2-Luc2 tumors, with significant signal reductions for the multi-point groups. The average pre-/post-treatment BLI flux (photons/s, ×10
conclusionsOur results suggest that a lower number of histotripsy pulses at fewer focal locations can achieve substantial tumor kill while minimizing hemorrhage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.