Evidence map›Paper›PMID 37494956›Full record

ArticleNature2023

Oligomerization-mediated activation of a short prokaryotic Argonaute.

Zhangfei Shen, Xiao-Yuan Yang, Shiyu Xia, Wei Huang, Derek J Taylor, Kotaro Nakanishi, Tian-Min Fu

Open access · greenAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
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  13. Article
  14. Characterization of Argonaute Nuclease from Mesophilic BacteriumInternational journal of molecular sciences · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Zhangfei Shen *Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-3707-2265
Xiao-Yuan Yang *Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-9763-1196
Shiyu XiaDivison of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0001-9024-0689
Wei HuangDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0000-0003-2097-8148
Derek J TaylorDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Kotaro NakanishiDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-9857-6010
Tian-Min FuDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH, USA. Fu.978@osu.edu.ORCID 0000-0002-6281-1752
The Ohio State University · USUniversity School · USCalifornia Institute of Technology · US

Funding

Target specificity of human RNA-induced silencing complexR01GM124320 · NIGMS · OHIO STATE UNIVERSITY · PI NAKANISHI, KOTARO · 2017 to 2025
$3.1M
Structural and molecular basis for cityRNA(cleavage-inducing tiny RNA)-directed RNA cleavage by AGO3R01GM138997 · NIGMS · OHIO STATE UNIVERSITY · PI NAKANISHI, KOTARO · 2020 to 2025
$2.1M
NIGMS NIH HHS R01 GM124320NIGMS NIH HHS R01 GM138997
6 · The paper itself

Abstract

Although eukaryotic and long prokaryotic Argonaute proteins (pAgos) cleave nucleic acids, some short pAgos lack nuclease activity and hydrolyse NAD(P)

Indexed as

Argonaute ProteinsProkaryotic CellsApoproteinsDNAEnzyme ActivationNADRNAApoproteinsArgonaute ProteinsDNANADRNA

Identifiers

PMID37494956
PMCPMC11332595
OpenAlexW4385281626

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.