Article in Science translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
17 authors.
Jordi BonaventuraDepartament de Patologia i Terapèutica Experimental, Institut de Neurociències, Universitat de Barcelona, Neuropharmacology and Pain Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Catalonia 08907, Spain.ORCID 0000-0002-4745-0151
Matthew A BoehmBiobehavioral Imaging and Molecular Neuropsychopharmacology Unit, Neuroimaging Research Branch, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA.ORCID 0000-0002-9977-270X
Hank P JedemaPreclinical Pharmacology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA.ORCID 0000-0002-7869-2110
Oscar SolisBiobehavioral Imaging and Molecular Neuropsychopharmacology Unit, Neuroimaging Research Branch, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA.ORCID 0000-0002-8285-5891
Marco PignatelliDepartment of Psychiatry and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Xiaowei SongPreclinical Pharmacology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA.ORCID 0000-0001-9694-6594
Hanbing LuMagnetic Resonance Imaging and Spectroscopy Section, Neuroimaging Research Branch, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA.ORCID 0000-0003-0469-4321
Christopher T RichieGenetic Engineering and Viral Vector Core, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA.ORCID 0000-0002-7944-4928
Shiliang ZhangConfocal and Electron Microscopy Core, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA.ORCID 0000-0001-8414-6178
Juan L GomezBiobehavioral Imaging and Molecular Neuropsychopharmacology Unit, Neuroimaging Research Branch, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA.ORCID 0000-0003-3170-9904
Sherry LamBiobehavioral Imaging and Molecular Neuropsychopharmacology Unit, Neuroimaging Research Branch, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA.
Marisela MoralesNeuronal Networks Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA.
Omar A GharbawieSystems Neuroscience Center, Departments of Neurobiology and Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Martin G PomperRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-6753-3010
Elliot A SteinNeuroimaging Research Branch, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA.ORCID 0000-0003-0593-0269
Charles W BradberryPreclinical Pharmacology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA.
Michael MichaelidesBiobehavioral Imaging and Molecular Neuropsychopharmacology Unit, Neuroimaging Research Branch, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA.ORCID 0000-0003-0398-4917
Funding
Multimodal preclinical imaging studies of decisional determinants of drug vs non-drug choiceZIADA000622 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI JEDEMA, HANK · 2017 to 2025
$21.9M
Biobehavioral Imaging and Molecular Neuropsychopharmacology of Substance Abuse MechanismsZIADA000069 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI MICHAELIDES, MICHAEL · 2016 to 2025
$18.9M
Training/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MARTIN G POMPER · 2017 to 2026
$11.8M
Functional and structural organization of motor areas in non-human primatesR01NS105697 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI EL GHARBAWIE, OMAR · 2019 to 2023
Optogenetics is a widely used technology with potential for translational research. A critical component of such applications is the ability to track the location of the transduced opsin in vivo. To address this problem, we engineered an excitatory opsin, ChRERα (hChR2(134R)-V5-ERα-LBD), that could be visualized using positron emission tomography (PET) imaging in a noninvasive, longitudinal, and quantitative manner. ChRERα consists of the prototypical excitatory opsin channelrhodopsin-2 (ChR2) and the ligand-binding domain (LBD) of the human estrogen receptor α (ERα). ChRERα showed conserved ChR2 functionality and high affinity for [
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Expression of the excitatory opsin ChRERα can be traced longitudinally in rat and nonhuman primate brains with PET imaging. · full record | OpenQuestion