Evidence map›Paper›PMID 37494452›Full record

ArticleScience advances2023

Phosphorylated nuclear DICER1 promotes open chromatin state and lineage plasticity of AT2 tumor cells in lung adenocarcinomas.

Raisa A Reyes-Castro, Shin-Yu Chen, Jacob Seemann, Samrat T Kundu, Don L Gibbons, Swathi Arur

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

  1. Cell-type Specific Alteration ofbioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Raisa A Reyes-CastroDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Shin-Yu ChenDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-8174-7741
Jacob SeemannDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-5113-9788
Samrat T KunduDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-0117-6986
Don L GibbonsDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-2362-3094
Swathi ArurDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-6941-2711
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
The Role of Epithelial-Mesenchymal Transition in Re-Wiring KRAS Mutant Lung CancerR37CA214609 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GIBBONS, DON LYNN · 2018 to 2024
$2.7M
NCI NIH HHS P30 CA016672NCI NIH HHS R37 CA214609
6 · The paper itself

Abstract

KRAS/ERK pathway phosphorylates DICER1, causing its nuclear translocation, and phosphomimetic

Indexed as

Adenocarcinoma of LungLung NeoplasmsMicroRNAsAnimalsChromatinDEAD-box RNA HelicasesHumansMiceProto-Oncogene Proteins p21(ras)Ribonuclease IIIChromatinDEAD-box RNA HelicasesDICER1 protein, humanMicroRNAsProto-Oncogene Proteins p21(ras)Ribonuclease III

Identifiers

PMID37494452
PMCPMC10371025
OpenAlexW4385282748

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.