ArticleProceedings of the National Academy of Sciences of the United States of America2023
ROS are evolutionary conserved cell-to-cell stress signals.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 62 citations in OpenAlex.
- Cell-based crop phenotyping for future climates.The New phytologist · 2026Review
- The Dark Side of Antioxidants: When Scavenging ROS Undermines Plant Stress Acclimation.Antioxidants (Basel, Switzerland) · 2026Review
- Plasmodesmata display dynamic local and systemic redox responses during plant stress.The Plant cell · 2026Article
- Exploring oxidative stress and epigenetic biomarkers in bees: insights into health effects of air pollution and diet - a pilot study.Environmental science and pollution research international · 2026Article
- Co-Culture of Mammalian Cells and Photosynthetic Microorganisms for Oxygen Supply in Engineered Tissues.Cell proliferation · 2026Article
- Species-Specific Effects of Humic Substances and Mycorrhiza on Antioxidant Defense and Metal Stress Tolerance inInternational journal of molecular sciences · 2026Article
- The secreted redox sensor roGFP2-Orp1 reveals oxidative dynamics in the plant apoplast.Plant biology (Stuttgart, Germany) · 2026Article
- Sculpting Microbial Microenvironments: Spatiotemporal Control via Programmable Electrochemical Gradients.Journal of the American Chemical Society · 2026Review
- The Host Coral Bleaching Response Viewed Through the Lens of Multi-Omics: Multi-Omics Provides the Tools to Understand the Complex Molecular Basis of Coral Bleaching, Which Can Aid Conservation Efforts.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Distinct physiological and functional responses in leaves and roots of co-occurring mangroves: contrasting invasiveFrontiers in plant science · 2026Article
- Typhoid toxin of Salmonella Typhi elicits host antimicrobial response during acute typhoid fever.EMBO molecular medicine · 2026Article
- The RALF-FERONIA Signaling Axis: A Central Hub Integrating Plant Growth, Reproduction, and Stress Responses.International journal of molecular sciences · 2025Review
- With or without a CaPlanta · 2025Article
- Article
- Eukaryogenesis From FECA to LECA: Radical Steps Along the Way.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Nitro-oxidative nucleotide modifications in plants and associated microorganisms: signalling sensors or stress symptoms?Journal of experimental botany · 2025Review
- Zeaxanthin and Other Carotenoids: Roles in Abiotic Stress Defense with Implications for Biotic Defense.Plants (Basel, Switzerland) · 2025Review
- Spatiotemporal HNature communications · 2025Article
- Redox-signaling in innate immune memory: Similar mechanisms in animals/humans and plants.Redox biology · 2025Review
- Sexual reproduction in land plants: an evolutionary perspective.Plant reproduction · 2025Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cell-to-cell communication is fundamental to multicellular organisms and unicellular organisms living in a microbiome. It is thought to have evolved as a stress- or quorum-sensing mechanism in unicellular organisms. A unique cell-to-cell communication mechanism that uses reactive oxygen species (ROS) as a signal (termed the "ROS wave") was identified in flowering plants. This process is essential for systemic signaling and plant acclimation to stress and can spread from a small group of cells to the entire plant within minutes. Whether a similar signaling process is found in other organisms is however unknown. Here, we report that the ROS wave can be found in unicellular algae, amoeba, ferns, mosses, mammalian cells, and isolated hearts. We further show that this process can be triggered in unicellular and multicellular organisms by a local stress or H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.