Evidence map›Paper›PMID 37494316›Full record

ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada2023

Genetic testing practices among specialist physicians who treat prostate cancer A Canadian, cross-sectional survey.

Steven M Yip, Christopher Morash, Michael P Kolinsky, Anil Kapoor, Michael Ong, Shamini Selvarajah, Jennifer Nuk, Katie Compton, Frederic Pouliot, Luke T Lavallée and 25 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Genetic testing practices among specialist physicians who treat prostate cancer Updated survey of Canadian practitioners.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 19 institutions in 2 countries.

Steven M YipTom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada.
Christopher MorashThe Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
Michael P KolinskyCross Cancer Institute, University of Alberta, Edmonton, AB, Canada.
Anil KapoorSt Joseph's Healthcare, McMaster University, Hamilton, ON, Canada.
Michael OngCross Cancer Institute, University of Alberta, Edmonton, AB, Canada.
Shamini SelvarajahDepartment of Clinical Laboratory Genetics, Laboratory Medicine Program, University Health Network (UHN), Toronto, ON, Canada.
Jennifer NukHereditary Cancer Program, BC Cancer, Vancouver, BC, Canada.
Katie ComptonHereditary Cancer Program, BC Cancer, Vancouver, BC, Canada.
Frederic PouliotCentre hospitalier universitaire de Québec, Université Laval, Quebec City, QC, Canada.
Luke T LavalléeDivision of Urology, Department of Surgery, University of Ottawa and Ottawa Hospital Research Institute Epidemiology Program, Ottawa, ON, Canada.
Daniel J KhalafDepartment of Medicine, Medical Oncology Division, BC Cancer, Vancouver Centre, University of British Columbia, Vancouver, BC, Canada.
Robert J HamiltonPrincess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.
Geoffrey T GottoSouthern Alberta Institute of Urology, University of Calgary, Calgary, AB, Canada.
Ricardo A RendonQueen Elizabeth II Health Sciences Centre, Dalhousie University, Halifax, NS, Canada.
Elie AntebiDepartment of Urology, University of Miami Miller School of Medicine, Miami, FL, USA.
Sebastien J HotteJuravinski Cancer Centre, McMaster University, Hamilton, ON, Canada.
Shawn MaloneThe Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
Kim N ChiBC Cancer Agency, University of British Columbia, Vancouver, BC, Canada.
Darrel E DrachenbergSection of Urology, Department of Surgery, University of Manitoba, Winnipeg, MB, Canada.
Fred SaadCentre Hospitalier de l'Université de Montréal, University of Montreal, Montreal, QC, Canada.
Jonathan ChanScarborough Health Network, University of Toronto, ON, Canada.
Cristiano FerrarioJewish General Hospital, McGill University, Montreal, QC, Canada.
Jenny KoDepartment of Medical Oncology, BC Cancer - Abbotsford, Abbotsford, BC, Canada.
Bobby ShayeganSt Joseph's Healthcare, McMaster University, Hamilton, ON, Canada.
Sunil ParimiDepartment of Medical Oncology, BC Cancer-Victoria, BC, Canada.
Alan I SoDepartment of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
Andrew FeiferDivision of Urology, Department of Surgery, University of Toronto, Toronto, ON Canada.
Kenneth JanszJoseph Brant Hospital, McMaster University, Burlington, ON, Canada.
Daygen FinchDepartment of Medical Oncology, BC Cancer Agency - Centre for the Southern Interior, Kelowna, BC, Canada.
Joseph L ChinDepartment of Surgery (Urology), University of Western Ontario, London Health Sciences Center, London, ON, Canada.
Brendan OsborneMedical Affairs, Janssen Inc, Toronto, ON, Canada.
Kai Fai HoSTAT-TU Inc., Elora, ON, Canada.
Corine Demanga GalamoMedical Affairs, Janssen Inc, Toronto, ON, Canada.
Anousheh ZardanMedical Affairs, Janssen Inc, Toronto, ON, Canada.
Tamim NiaziJewish General Hospital, McGill University, Montreal, QC, Canada.
BC Cancer Agency · CAMcMaster University · CAOttawa Hospital · CAUniversity of Alberta · CAUniversity of British Columbia · CAUniversity of Calgary · CAUniversity of Toronto · CAAbbotsford Veterinary Clinic · CACentre Hospitalier de l’Université de Montréal · CADalhousie University · CAJewish General Hospital · CAJuravinski Cancer Centre · CALondon Health Sciences Centre · CAMcGill University · CAThe Scarborough Hospital · CAUniversité Laval · CAUniversity Health Network · CAUniversity of Manitoba · CAUniversity of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn patients with prostate cancer (PCa), the identification of an alteration in genes associated with homologous recombination repair (HRR) has implications for prognostication, optimization of therapy, and familial risk mitigation. The aim of this study was to assess the genomic testing landscape of PCa in Canada and to recommend an approach to offering germline and tumor testing for HRR-associated genes.

methodsThe Canadian Genitourinary Research Consortium (GURC) administered a cross-sectional survey to a largely academic, multidisciplinary group of investigators across 22 GURC sites between January and June 2022.

resultsThirty-eight investigators from all 22 sites responded to the survey. Germline genetic testing was initiated by 34%, while 45% required a referral to a genetic specialist. Most investigators (82%) reported that both germline and tumor testing were needed, with 92% currently offering germline and 72% offering tissue testing to patients with advanced PCa. The most cited reasons for not offering testing were an access gap (50%), uncertainties around who to test and which genes to test, (33%) and interpreting results (17%). A majority reported that patients with advanced PCa (74-80%) should be tested, with few investigators testing patients with localized disease except when there is a family history of PCa (45-55%).

conclusionsCanadian physicians with academic subspecialist backgrounds in genitourinary malignancies recognize the benefits of both germline and somatic testing in PCa; however, there are challenges in accessing testing across practices and specialties. An algorithm to reduce uncertainty for providers when ordering genetic testing for patients with PCa is proposed.

Identifiers

PMID37494316
PMCPMC10581730
OpenAlexW4385074059

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.