ArticleCell reports2023
Electrophysiological signatures of inequity-dependent reward encoding in the human OFC.
Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Intracranial recordings in humans reveal differential contributions of medial and lateral orbitofrontal cortex to approach-avoidance decision-making.Nature neuroscience · 2026Article
- Cognitive deficits linked to intrinsic timescales and gray matter volume abnormalities in children with Duchenne muscular dystrophy.Journal of neurodevelopmental disorders · 2026Article
- Neural effect of childhood maltreatment on neurovascular coupling in adolescent depression.European child & adolescent psychiatry · 2025Article
- Simultaneous intracranial recordings of interacting brains reveal neurocognitive dynamics of human cooperation.Nature neuroscience · 2025Article
- Effects of three exercise interventions on inhibitory control in college students with internet addiction: a functional near-infrared spectroscopy study.Frontiers in psychology · 2025Article
- Human Substantia Nigra Neurons Encode Reward Expectations.bioRxiv : the preprint server for biology · 2024Article
- Encoding of Predictive Associations in Human Prefrontal and Medial Temporal Neurons During Pavlovian Appetitive Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Social decision making requires the integration of reward valuation and social cognition systems, both dependent on the orbitofrontal cortex (OFC). How these two OFC functions interact is largely unknown. We recorded intracranial activity from the OFC of ten patients making choices in a social context where reward inequity with a social counterpart varied and could be either advantageous or disadvantageous. We find that OFC high-frequency activity (HFA; 70-150 Hz) encodes self-reward, consistent with previous reports. We also observe encoding of the social counterpart's reward, as well as the type of inequity being experienced. Additionally, we find evidence of inequity-dependent reward encoding: depending on the type of inequity, electrodes rapidly and reversibly switch between different reward-encoding profiles. These results provide direct evidence for encoding of self- and other rewards in the human OFC and highlight the dynamic nature of encoding in the OFC as a function of social context.
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