Evidence map›Paper›PMID 37494051›Full record

Trial reportCirculation. Heart failure2023

DASH-HF Study: A Pragmatic Quality Improvement Randomized Implementation Trial for Patients With Heart Failure With Reduced Ejection Fraction.

Aradhana Verma, Gregg C Fonarow, Jeffrey J Hsu, Cynthia A Jackevicius, Freny Vaghaiwalla Mody, Amanda Nguyen, Omid Amidi, Sarah Goldberg, Reeta Vetrivel, Deepti Upparapalli and 6 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled TrialPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation. Heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05001165 (Dashboard Activated Services and Tele-Health for Heart Failure), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05001165 nacompletednot on this map

Dashboard Activated Services and Tele-Health for Heart Failure

TypeinterventionalSponsorVA Greater Los Angeles Healthcare SystemRan2021 to 2022Enrolled300ConditionsHeart Failure With Reduced Ejection FractionArmsProactive Panel Management Clinics for HFrEF
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Aradhana VermaDepartment of Medicine (A.V., A.N.), David Geffen School of Medicine at the University of California, Los Angeles.ORCID 0000-0002-8877-2325
Gregg C FonarowDivision of Cardiology (G.C.F., J.J.H., O.A., D.U., K.T., K.B., B.Z.), David Geffen School of Medicine at the University of California, Los Angeles.ORCID 0000-0002-3192-8093
Jeffrey J HsuDivision of Cardiology (G.C.F., J.J.H., O.A., D.U., K.T., K.B., B.Z.), David Geffen School of Medicine at the University of California, Los Angeles.ORCID 0000-0002-9971-5916
Cynthia A JackeviciusDepartment of Pharmacy Practice and Administration, Western University of Health Sciences, Pomona, CA (C.A.J.).ORCID 0000-0001-5274-7251
Freny Vaghaiwalla ModyDivision of Cardiology, VA Greater Los Angeles Healthcare System, CA (J.J.H., F.V.M., S.G., R.V., D.S.C., K.B., B.Z.).
Amanda NguyenDepartment of Medicine (A.V., A.N.), David Geffen School of Medicine at the University of California, Los Angeles.
Omid AmidiDivision of Cardiology (G.C.F., J.J.H., O.A., D.U., K.T., K.B., B.Z.), David Geffen School of Medicine at the University of California, Los Angeles.
Sarah GoldbergDivision of Cardiology, VA Greater Los Angeles Healthcare System, CA (J.J.H., F.V.M., S.G., R.V., D.S.C., K.B., B.Z.).
Reeta VetrivelDivision of Cardiology, VA Greater Los Angeles Healthcare System, CA (J.J.H., F.V.M., S.G., R.V., D.S.C., K.B., B.Z.).
Deepti UpparapalliDivision of Cardiology (G.C.F., J.J.H., O.A., D.U., K.T., K.B., B.Z.), David Geffen School of Medicine at the University of California, Los Angeles.
Kleanthis TheodoropoulosDivision of Cardiology (G.C.F., J.J.H., O.A., D.U., K.T., K.B., B.Z.), David Geffen School of Medicine at the University of California, Los Angeles.
Stephanie GregorioDepartment of Pharmacy, VA Greater Los Angeles Healthcare System, CA (C.A.J., S.G.).ORCID 0000-0002-6383-6898
Donald S ChangDivision of Cardiology, VA Greater Los Angeles Healthcare System, CA (J.J.H., F.V.M., S.G., R.V., D.S.C., K.B., B.Z.).
Kristina BostromDivision of Cardiology (G.C.F., J.J.H., O.A., D.U., K.T., K.B., B.Z.), David Geffen School of Medicine at the University of California, Los Angeles.ORCID 0000-0002-7745-5025
Andrew D AlthouseDepartment of Medicine, University of Pittsburgh, PA (A.D.A.).ORCID 0000-0002-8654-5014
Boback ZiaeianDivision of Cardiology (G.C.F., J.J.H., O.A., D.U., K.T., K.B., B.Z.), David Geffen School of Medicine at the University of California, Los Angeles.ORCID 0000-0001-9787-3649
University of California, Los Angeles · USVA Greater Los Angeles Healthcare System · USUniversity of Pittsburgh · USWestern University · CA

Funding

The Effect of Nanoparticle Encapsulated Resveratrol on Treatment of PeriodontitisKL2TR001882 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeta Nemeth · 2016 to 2026
$13.1M
Mechanobiology of Endothelial-to-Mesenchymal Transition in Cardiovascular CalcificationK08HL151961 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSU, JEFFREY JOHN · 2020 to 2024
$646k
NCATS NIH HHS KL2 TR001882NHLBI NIH HHS K08 HL151961
6 · The paper itself

Abstract

backgroundHeart failure is a prevailing diagnosis of hospitalization and readmission within 6 months, and nearly a quarter of these patients die within a year. Guideline-directed medication therapies reduce risk of mortality by 73% over 2 years; however, the implementation of these therapies to their target dose in clinical practice continues to be challenging. In 2020, the Veterans Affairs (VA) Health Care System developed a HF dashboard to monitor and improve outpatient HF management. The DASH-HF (Dashboard Activated Services and Telehealth for Heart Failure) study is a randomized, pragmatic clinical trial to evaluate proactive dashboard-directed telehealth clinics to improve the use and dosing of guideline-directed medication therapy for patients with heart failure with reduced ejection fraction not on optimal guideline-directed medication therapy within the VA.

methodsThree hundred veterans with heart failure with reduced ejection fraction met inclusion criteria with an optimization potential score (OPS) of 5 or less out of 10, representing nonoptimal guideline-directed medication therapy. The primary outcome was a composite score of guideline-directed medical therapy, the OPS, 6 months after the end of the intervention. Secondary outcomes included active prescriptions for each individual guideline-directed medical therapy class, HF-related hospitalizations, deaths, and clinician time per patient during the intervention clinics.

resultsThere was no significant difference between the intervention arm and usual care group in the primary outcome (OPS, 2.9; SD=2.1 versus OPS, 2.6, SD=2.1); adjusted mean difference 0.3 (95% CI, -0.1 to 0.7) or in the prespecified secondary outcomes for hospitalization and all-cause mortality for the intervention of proactive dashboard-based clinics.

conclusionsA dashboard-based clinic intervention did not improve the OPS or secondary outcomes of hospitalization and all-cause mortality. There remains a larger opportunity to better target patients and provide more intensive follow-up to further evaluate the utility of proactive dashboard-based clinics for HF management and quality improvement. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT05001165.

Indexed as

Heart FailureVentricular Dysfunction, LeftHospitalizationHumansQuality ImprovementStroke Volumeguideline-directed medical therapyheart failure with reduced ejection fractionmedicationsquality improvementtelehealth

Identifiers

PMID37494051
PMCPMC10524378
OpenAlexW4385264261

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.