Evidence map›Paper›PMID 37493767›Full record

ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2023

Astragaloside IV alleviates lung inflammation in Klebsiella pneumonia rats by suppressing TGF-β1/Smad pathway.

Lei Li, Jie Guan, Rongjun Lin, Fang Wang, Hui Ma, Chenggang Mao, Xingqing Guo, Zhenghai Qu, Renzheng Guan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lei LiDepartment of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, China.ORCID http://orcid.org/0009-0005-3231-1027
Jie GuanDepartment of Neurology, Qingdao Hiser Hospital Affiliated to Qingdao University (Qingdao Traditional Chinese Medicine Hospital), Qingdao, China.ORCID http://orcid.org/0009-0005-7215-2737
Rongjun LinDepartment of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, China.ORCID http://orcid.org/0000-0002-1333-0223
Fang WangDepartment of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, China.ORCID http://orcid.org/0009-0009-4519-1895
Hui MaDepartment of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, China.ORCID http://orcid.org/0009-0002-1211-1122
Chenggang MaoDepartment of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, China.ORCID http://orcid.org/0009-0001-8403-9783
Xingqing GuoDepartment of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, China.ORCID http://orcid.org/0000-0002-0333-0561
Zhenghai QuDepartment of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, China.ORCID http://orcid.org/0000-0002-4684-8651
Renzheng GuanDepartment of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, China.ORCID http://orcid.org/0000-0002-0196-8094
Qingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astragaloside IV is a biologically active substance derived from the traditional Chinese medicine Astragalus mambranaceus Bunge, and has antioxidant, anti-inflammatory, and anti-apoptotic properties. In this study, we aimed to investigate the effects of astragaloside IV on Klebsiella pneumonia rats and the underlying mechanisms. Klebsiella pneumoniae (K. pneumoniae) rats were treated with different dosages of astragaloside IV (5, 10, and 20 mg/kg) by intragastric administration. The levels of pro-inflammatory cytokines interleukin (IL)-6, IL-1β, and tumor necrosis factor (TNF)-α in bronchoalveolar lavage fluid (BALF) were determined. Pathological changes of lung tissue were inspected by HE staining. The expression of transforming growth factor (TGF)-β1 in lung tissue was determined with immunohistochemistry, and the expression levels of TGF-β1, p-Smad2/Smad2, p-Smad3/Smad3, IκBα/p-IκBα, and p65/p-p65 in lung tissue were determined by western blot. The mechanism was further investigated with TGF-β1 inhibitor SB-431542. Astragaloside IV reduced the elevated levels of pro-inflammatory cytokines caused by K. pneumoniae and improved lung tissue damage in a dose-dependent manner. Astragaloside IV also decreased the expression of TGF-β1/Smad signaling pathway-related proteins and decreased the protein levels of inflammation-related p-IκBα and p65 in lung tissues induced by K. pneumoniae. Additionally, it was found that the effects of 20 mg/kg astragaloside IV were similar to SB-431542, which could improve pulmonary fibrosis induced by K. pneumoniae, decrease the levels of TGF-β1/Smad signaling pathway-related proteins in lung, and reduce inflammation at the same time. Astragaloside IV could alleviate the inflammation of rat pneumonia induced by K. pneumoniae through suppressing the TGF-β1/Smad pathway.

Indexed as

PneumoniaTransforming Growth Factor beta1AnimalsBenzamidesCytokinesDioxolesInflammationKlebsiella pneumoniaeNF-KappaB Inhibitor alphaRatsSaponinsTriterpenes4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideastragaloside ABenzamidesCytokinesDioxolesNF-KappaB Inhibitor alphaSaponinsTransforming Growth Factor beta1Triterpenes

Identifiers

PMID37493767
PMCPMC10361639
OpenAlexW4385153521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.