Evidence map›Paper›PMID 37493633›Full record

ArticlemBio2023

Molecular determinants of avoidance and inhibition of

Silvia Gervasoni, Jitender Mehla, Charles R Bergen, Inga V Leus, Enrico Margiotta, Giuliano Malloci, Andrea Bosin, Attilio V Vargiu, Olga Lomovskaya, Valentin V Rybenkov and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  9. Recent advances in anti-infective drug discovery · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Silvia GervasoniDepartment of Physics, University of Cagliari , Monserrato, Italy.
Jitender MehlaDepartment of Chemistry and Biochemistry, University of Oklahoma , Norman, Oklahoma, USA.ORCID 0000-0002-7829-557X
Charles R BergenDepartment of Chemistry and Biochemistry, University of Oklahoma , Norman, Oklahoma, USA.
Inga V LeusDepartment of Chemistry and Biochemistry, University of Oklahoma , Norman, Oklahoma, USA.ORCID 0000-0001-8906-717X
Enrico MargiottaDepartment of Physics, University of Cagliari , Monserrato, Italy.
Giuliano MallociDepartment of Physics, University of Cagliari , Monserrato, Italy.
Andrea BosinDepartment of Physics, University of Cagliari , Monserrato, Italy.
Attilio V VargiuDepartment of Physics, University of Cagliari , Monserrato, Italy.
Olga LomovskayaQpex Biopharma , San Diego, California, USA.ORCID 0000-0001-8637-3139
Valentin V RybenkovDepartment of Chemistry and Biochemistry, University of Oklahoma , Norman, Oklahoma, USA.ORCID 0000-0002-5300-4369
Paolo RuggeroneDepartment of Physics, University of Cagliari , Monserrato, Italy.ORCID 0000-0003-0825-0824
Helen I ZgurskayaDepartment of Chemistry and Biochemistry, University of Oklahoma , Norman, Oklahoma, USA.ORCID 0000-0001-8929-4727
University of Cagliari · ITUniversity of Oklahoma · USMapp Biopharmaceutical (United States) · US

Funding

Optimization of efflux avoidance and inhibition for antibiotic developmentR01AI136799 · NIAID · UNIVERSITY OF OKLAHOMA · PI GNANAKARAN, SANDRASEGARAM, RUGGERONE, PAOLO · 2018 to 2022
$5.7M
Permeability Barriers of Gram-negative Pathogens and Approaches to Bypass ThemR01AI132836 · NIAID · UNIVERSITY OF OKLAHOMA · PI HELEN I ZGURSKAYA · 2017 to 2026
$4.3M
Small Molecule Inhibition of a Multidrug Efflux Pump of Pseudomonas aeruginosaR03AI163845 · NIAID · UNIVERSITY OF OKLAHOMA · PI ZGURSKAYA, HELEN I · 2021 to 2022
$141k
NIAID NIH HHS R01 AI132836NIAID NIH HHS R01 AI136799NIAID NIH HHS R03 AI163845
6 · The paper itself

Abstract

Transporters of the resistance-nodulation-cell division (RND) superfamily of proteins are the dominant multidrug efflux power of Gram-negative bacteria. The major RND efflux pump of

Indexed as

Bacterial Outer Membrane ProteinsPseudomonas aeruginosaLigandsMembrane Transport ProteinsMicrobial Sensitivity TestsBacterial Outer Membrane ProteinsLigandsMembrane Transport Proteinsantibiotic resistanceefflux pump inhibitorsmachine learningmultidrug effluxPseudomonas aeruginosa

Identifiers

PMID37493633
PMCPMC10470492
OpenAlexW4385264770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.