Evidence map›Paper›PMID 37493605›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2023

Vitamin C Deficiency Deteriorates Bone Microarchitecture and Mineralization in a Sex-Specific Manner in Adult Mice.

Stéphane Blouin, Farzaneh Khani, Phaedra Messmer, Paul Roschger, Markus A Hartmann, Andre J van Wijnen, Roman Thaler, Barbara M Misof

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Stéphane BlouinLudwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1st Med. Dept. Hanusch Hospital, Vienna, Austria.ORCID 0000-0001-6575-8443
Farzaneh KhaniDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Phaedra MessmerLudwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1st Med. Dept. Hanusch Hospital, Vienna, Austria.
Paul RoschgerLudwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1st Med. Dept. Hanusch Hospital, Vienna, Austria.
Markus A HartmannLudwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1st Med. Dept. Hanusch Hospital, Vienna, Austria.ORCID 0000-0001-6046-0365
Andre J van WijnenDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.ORCID 0000-0002-4458-0946
Roman ThalerDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-5515-8719
Barbara M MisofLudwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1st Med. Dept. Hanusch Hospital, Vienna, Austria.ORCID 0000-0001-9923-4920
Hanusch Hospital · ATMayo Clinic in Arizona · USUniversity of Vermont · US

Funding

Institutional Career Development CoreKL2TR002379 · NCATS · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2017 to 2026
$14.9M
Molecular Control of Bone FormationR01AR049069 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WESTENDORF, JENNIFER J · 2003 to 2021
$5.8M
NCATS NIH HHS KL2 TR002379NIAMS NIH HHS R01 AR049069NIH HHSNIH HHS AR049069
6 · The paper itself

Abstract

Vitamin C (VitC) is essential for bone health, and low VitC serum levels increase the risk for skeletal fractures. If and how VitC affects bone mineralization is unclear. Using micro-computed tomography (μCT), histologic staining, as well as quantitative backscattered electron imaging (qBEI), we assessed the effects of VitC on femoral structure and microarchitecture, bone formation, and bone mineralization density distribution (BMDD) in the VitC incompetent Gulo

Indexed as

Ascorbic Acid DeficiencyMustelidaeAnimalsAscorbic AcidBone and BonesBone DensityCalcification, PhysiologicCalciumFemaleMaleMiceX-Ray MicrotomographyAscorbic AcidCalciumASCORBATEBONE GEOMETRY AND MICROARCHITECTUREBONE MATRIX MINERALIZATIONGulo−/− MICEOSTEOPENIAQUANTITATIVE BACKSCATTERED ELECTRON IMAGING (qBEI)μCT

Identifiers

PMID37493605
PMCPMC10636228
OpenAlexW4385263695

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.