Evidence map›Paper›PMID 37493524›Full record

ArticleIUCrJ2023

MRC2020: improvements to Ximdisp and the MRC image-processing programs.

J M Short, C M Palmer, T Burnley, M D Winn, Q Zhang, B V Venkataram Prasad, S Chen, R A Crowther, P N T Unwin, R Henderson

Abstract read
In one paragraph

Article in IUCrJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Influence of lipid bilayer on the structure of the muscle-type nicotinic acetylcholine receptor.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

J M ShortMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0002-9008-6607
C M PalmerScience & Technology Facilities Council, Research Complex at Harwell, Harwell, Didcot OX11 0FA, United Kingdom.ORCID 0000-0002-4883-1546
T BurnleyScience & Technology Facilities Council, Research Complex at Harwell, Harwell, Didcot OX11 0FA, United Kingdom.ORCID 0000-0001-5307-348X
M D WinnScience & Technology Facilities Council, Research Complex at Harwell, Harwell, Didcot OX11 0FA, United Kingdom.ORCID 0000-0003-0496-6796
Q ZhangSun Yat Sen University, School of Life Science, State Key Laboratory of Biocontrol, Guangzhou 510275, People's Republic of China.ORCID 0000-0001-6599-8105
B V Venkataram PrasadVerna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-1172-2071
S ChenMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0002-9472-4397
R A CrowtherMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0003-0568-1426
P N T UnwinMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0002-1368-1648
R HendersonMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0003-1444-0528

Funding

X-ray Crystallographic Studies on CalicivirusesP01AI057788 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI ATMAR, ROBERT L., ESTES, MARY KOLB · 2004 to 2024
$34.4M
Medical Research Council MC_U105184294Medical Research Council MC_U105184322Medical Research Council MR/V000403/1NIAID NIH HHS P01 AI057788NIH HHS PO1 AI057788
6 · The paper itself

Abstract

The great success of single-particle electron cryo-microscopy (cryoEM) during the last decade has involved the development of powerful new computer programs and packages that guide the user along a recommended processing workflow, in which the wisdom and choices made by the developers help everyone, especially new users, to obtain excellent results. The ability to carry out novel, non-standard or unusual combinations of image-processing steps is sometimes compromised by the convenience of a standard procedure. Some of the older programs were written with great flexibility and are still very valuable. Among these, the original MRC image-processing programs for structure determination by 2D crystal and helical processing alongside general-purpose utility programs such as Ximdisp, label, imedit and twofile are still available. This work describes an updated version of the MRC software package (MRC2020) that is freely available from CCP-EM. It includes new features and improvements such as extensions to the MRC format that retain the versatility of the package and make it particularly useful for testing novel computational procedures in cryoEM.

Indexed as

cryoEMimage-processing programsMRC2020

Identifiers

PMID37493524
PMCPMC10478516

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.