Evidence map›Paper›PMID 37493373›Full record

ArticleAntimicrobial agents and chemotherapy2023

ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant

Min Xie, Uday S Ganapathy, Tian Lan, Paulina Osiecki, Jansy P Sarathy, Véronique Dartois, Courtney C Aldrich, Thomas Dick

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Next-generation rifamycins for the treatment of mycobacterial infections.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Toward better cures forClinical microbiology reviews · 2024
    Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Min XieCenter for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA.
Uday S GanapathyCenter for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA.
Tian LanDepartment of Medicinal Chemistry, College of Pharmacy, University of Minnesota , Minneapolis, Minnesota, USA.
Paulina OsieckiCenter for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA.
Jansy P SarathyCenter for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA.
Véronique DartoisCenter for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA.
Courtney C AldrichDepartment of Medicinal Chemistry, College of Pharmacy, University of Minnesota , Minneapolis, Minnesota, USA.
Thomas DickCenter for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA.ORCID 0000-0002-9604-9452
Hackensack Meridian Health · USUniversity of Minnesota · USGeorgetown University · US

Funding

Therapeutics for drug-resistant bacteria: aryl myxopyronins and arylalkylcarboxamido phloroglucinolsU19AI142731 · NIAID · HACKENSACK UNIVERSITY MEDICAL CENTER · PI PERLIN, DAVID S · 2019 to 2023
$33.9M
Discovery of novel lead-target pairs and identification of all-oral bactericidal drug regimens for Mycobacterium abscessus lung diseaseR01AI132374 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI Thomas Dick · 2018 to 2026
$7.0M
Optimization of rifamycins to overcome intrinsic resistance of nontuberculous mycobacteria to improve treatment of NTM lung diseaseR01AI177342 · NIAID · HACKENSACK UNIVERSITY MEDICAL CENTER · PI Courtney C Aldrich, Thomas Dick · 2023 to 2026
$3.4M
NIAID NIH HHS R01 AI132374NIAID NIH HHS R01 AI177342NIAID NIH HHS U19 AI142731
6 · The paper itself

Abstract

Necrotic lesions and cavities filled with caseum are a hallmark of mycobacterial pulmonary disease. Bronchocavitary

Indexed as

Mycobacterium abscessusMycobacterium Infections, NontuberculousRifamycinsAnti-Bacterial AgentsHumansMicrobial Sensitivity TestsRifabutinAnti-Bacterial AgentsRifabutinRifamycinsADP-ribosylasecaseumdrug tolerancenon-tuberculous mycobacteriaNTMpersistencerifamycins

Identifiers

PMID37493373
PMCPMC10508146
OpenAlexW4385264016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.