Evidence map›Paper›PMID 37493283›Full record

ArticleCell transplantation

Nonhematopoietic Umbilical Cord Blood Stem Cell Administration Improves Long-term Neurodevelopment After Periventricular-Intraventricular Hemorrhage in Neonatal Rats.

Raghavendra B Rao, Maple L Shiao, Kathleen M Ennis-Czerniak, Walter C Low

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Raghavendra B RaoDivision of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0000-0002-6089-5972
Maple L ShiaoDepartment of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN, USA.
Kathleen M Ennis-CzerniakDivision of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
Walter C LowDepartment of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0000-0001-8593-0175
University of Minnesota · USUniversity of Minnesota Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periventricular-intraventricular hemorrhage (PIVH) is common in extremely low gestational age neonates (ELGAN) and leads to motor and behavioral impairments. Currently there is no effective treatment for PIVH. Whether human nonhematopoietic umbilical cord blood-derived stem cell (nh-UCBSC) administration reduces the severity of brain injury and improves long-term motor and behavioral function was tested in an ELGAN-equivalent neonatal rat model of PIVH. In a collagenase-induced unilateral PIVH on postnatal day (P) 2 model, rat pups received a single dose of nh-UCBSCs at a dose of 1 × 10

Indexed as

Cerebral HemorrhageFetal BloodAnimalsAnimals, NewbornGestational AgeHumansRatsStem Cellsbrain injuryextremely low gestational age neonateshuman umbilical cord bloodnonhematopoietic umbilical cord blood stem cellsperiventricular-intraventricular hemorrhagepreterm infants

Identifiers

PMID37493283
PMCPMC10387682
OpenAlexW4385264349

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.