Observational studyPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2023
Early emollient bathing is associated with subsequent atopic dermatitis in an unselected birth cohort study.
Observational study in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Early emollient bathing is associated with subsequent atopic dermatitis in an unselected birth cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2023Observational
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6 authors.
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Abstract
backgroundSkin barrier dysfunction is a key component of the pathogenesis of atopic dermatitis (AD). Recent research on barrier optimization to prevent AD has shown mixed results. The aim of this study was to assess the relationship between emollient bathing at 2 months and the trajectory of AD in the first 2 years of life in a large unselected observational birth cohort study.
methodsThe Babies After SCOPE: Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints Birth Cohort study enrolled 2183 infants. Variables extracted from the database related to early skincare, skin barrier function, parental history of atopy, and AD outcomes. Statistical analysis was performed to adjust for potential confounding variables.
resultsOne thousand five hundred five children had data on AD status available at 6, 12, and 24 months. Prevalence of AD was 18.6% at 6 months, 15.2% at 12 months, and 16.5% at 24 months. Adjusted for potential confounding variables, the odds of AD at any point were higher among infants who had emollient baths at 2 months (OR (95% CI): 2.41 (1.56 to 3.72), p < .001). Following multivariable analysis, the odds of AD were higher among infants who had both emollient baths and frequent emollient application at 2 months, compared with infants who had neither (OR (95% CI) at 6 months 1.74 (1.18-2.58), p = .038), (OR (95% CI) at 12 months 2.59 (1.69-3.94), p < .001), (OR (95% CI) at 24 months 1.87 (1.21-2.90), p = .009).
conclusionEarly emollient bathing was associated with greater development of AD by 2 years of age in this population-based birth cohort study.
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