Evidence map›Paper›PMID 37492723›Full record

ReviewGenes & diseases2023

Hereditary severe insulin resistance syndrome: Pathogenesis, pathophysiology, and clinical management.

Junaid Iqbal, Hong-Li Jiang, Hui-Xuan Wu, Long Li, Ying-Hui Zhou, Nan Hu, Fen Xiao, Ting Wang, Shi-Na Xu, Hou-De Zhou

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes & diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Severe Insulin Resistance Syndromes: Clinical Spectrum and Management.International journal of molecular sciences · 2025
    Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Junaid IqbalNational Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, and Department of Endocrinology and Metabolism, The Second XiangYa Hospital of Central South University, Changsha, Hunan 410011, China.
Hong-Li JiangNational Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, and Department of Endocrinology and Metabolism, The Second XiangYa Hospital of Central South University, Changsha, Hunan 410011, China.
Hui-Xuan WuNational Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, and Department of Endocrinology and Metabolism, The Second XiangYa Hospital of Central South University, Changsha, Hunan 410011, China.
Long LiNational Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, and Department of Endocrinology and Metabolism, The Second XiangYa Hospital of Central South University, Changsha, Hunan 410011, China.
Ying-Hui ZhouNational Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, and Department of Endocrinology and Metabolism, The Second XiangYa Hospital of Central South University, Changsha, Hunan 410011, China.
Nan HuNational Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, and Department of Endocrinology and Metabolism, The Second XiangYa Hospital of Central South University, Changsha, Hunan 410011, China.
Fen XiaoNational Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, and Department of Endocrinology and Metabolism, The Second XiangYa Hospital of Central South University, Changsha, Hunan 410011, China.
Ting WangNational Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, and Department of Endocrinology and Metabolism, The Second XiangYa Hospital of Central South University, Changsha, Hunan 410011, China.
Shi-Na XuNational Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, and Department of Endocrinology and Metabolism, The Second XiangYa Hospital of Central South University, Changsha, Hunan 410011, China.
Hou-De ZhouNational Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, and Department of Endocrinology and Metabolism, The Second XiangYa Hospital of Central South University, Changsha, Hunan 410011, China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe insulin resistance has been linked to some of the most globally prevalent disorders, such as diabetes mellitus, nonalcoholic fatty liver disease, polycystic ovarian syndrome, and hypertension. Hereditary severe insulin resistance syndrome (H-SIRS) is a rare disorder classified into four principal categories: primary insulin receptor defects, lipodystrophies, complex syndromes, and obesity-related H-SIRS. Genes such as

Indexed as

DiabetesGeneticsInsulin resistanceLipodystrophyPathophysiologyTherapy

Identifiers

PMID37492723
PMCPMC10363564
OpenAlexW4223654042

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.