ReviewFrontiers in toxicology2023
New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens-a PARC project.
Abstract readReview
In one paragraph
Review in Frontiers in toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- The Art of Domesticating Proteins: How Cancer Cells Adapt to Therapeutic and Environmental Stressors.International journal of molecular sciences · 2026Review
- "The Dose Makes the Poison": Relevance of Paracelsus's Principle for Modern Chemical Hazard Assessment with New Approach Methodologies.Environmental science & technology · 2026Article
- From prioritization to implementation: updating the PARC WP5 project portfolio through the second prioritization round.Frontiers in toxicology · 2026Review
- Nucleophosmin 1 induction is an early event in a Phenobarbital induced proliferation response in rat but not human liver 3D microtissues.Toxicology reports · 2025Article
- Integrating New Approach Methodologies (NAMs) into Preclinical Regulatory Evaluation of Oncology Drugs.Biomimetics (Basel, Switzerland) · 2025Review
- The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals.Archives of toxicology · 2025Article
- A modular strategy for the testing and assessment of non-genotoxic carcinogens.Archives of toxicology · 2024Article
- Finding a Direct Method for a Dynamic Process: The DD (Direct and Dynamic) Cell-Tox Method.International journal of molecular sciences · 2024Article
- Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps.Frontiers in toxicology · 2024Article
- Assessing human carcinogenicity risk of agrochemicals without the rodent cancer bioassay.Frontiers in toxicology · 2024Article
- Heme Oxygenase-1 and Its Role in Colorectal Cancer.Antioxidants (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors.
Marc AudebertINRAE: Toxalim, INRAE, INP-ENVT, INP-EI-Purpan, Université de Toulouse 3 Paul Sabatier, Toulouse, France.
Ann-Sophie AssmannDepartment Experimental Toxicology and ZEBET, German Centre for the Protection of Laboratory Animals (Bf3R) and Department Food Safety, BfR: German Federal Institute for Risk Assessment, Berlin, Germany.
Amaya AzquetaDepartment of Pharmacology and Toxicology, School of Pharmacy and Nutrition, UNAV: University of Navarra, Pamplona, Spain.
Pavel BabicaRECETOX: RECETOX, Faculty of Science, Masaryk University, Brno, Czechia.
Emilio BenfenatiIRFMN: Istituto di Ricerche Farmacologiche Mario Negri-IRCCS, Milan, Italy.
Sylvie BortoliINSERM: INSERM UMR-S 1124 T3S-Université Paris Cité, Paris, France.
Peter BouwmanUL-LACDR: Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.
Albert BraeuningDepartment Experimental Toxicology and ZEBET, German Centre for the Protection of Laboratory Animals (Bf3R) and Department Food Safety, BfR: German Federal Institute for Risk Assessment, Berlin, Germany.
Tanja BurgdorfDepartment Experimental Toxicology and ZEBET, German Centre for the Protection of Laboratory Animals (Bf3R) and Department Food Safety, BfR: German Federal Institute for Risk Assessment, Berlin, Germany.
Xavier CoumoulINSERM: INSERM UMR-S 1124 T3S-Université Paris Cité, Paris, France.
Kloé DebizetINSERM: INSERM UMR-S 1124 T3S-Université Paris Cité, Paris, France.
Maria DusinskaHealth Effects Laboratory, NILU: The Climate and Environmental Research Institute, Kjeller, Norway.
Norman ErtychDepartment Experimental Toxicology and ZEBET, German Centre for the Protection of Laboratory Animals (Bf3R) and Department Food Safety, BfR: German Federal Institute for Risk Assessment, Berlin, Germany.
Jörg FahrerDepartment of Chemistry, RPTU: Division of Food Chemistry and Toxicology, Kaiserslautern, Germany.
Verena FetzDepartment Experimental Toxicology and ZEBET, German Centre for the Protection of Laboratory Animals (Bf3R) and Department Food Safety, BfR: German Federal Institute for Risk Assessment, Berlin, Germany.
Ludovic Le HégaratANSES: French Agency for Food, Environmental and Occupational Health and Safety, Fougères Laboratory, Toxicology of Contaminants Unit, Fougères, France.
Adela López de CerainDepartment of Pharmacology and Toxicology, School of Pharmacy and Nutrition, UNAV: University of Navarra, Pamplona, Spain.
Harm J HeusinkveldRIVM: National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Kevin HogeveenANSES: French Agency for Food, Environmental and Occupational Health and Safety, Fougères Laboratory, Toxicology of Contaminants Unit, Fougères, France.
Miriam N JacobsRadiation, Chemical and Environmental Hazards, UKHSA: UK Health Security Agency, Chilton, Oxfordshire, United Kingdom.
Mirjam LuijtenRIVM: National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Giuseppa RaitanoIRFMN: Istituto di Ricerche Farmacologiche Mario Negri-IRCCS, Milan, Italy.
Cynthia RecoulesINRAE: Toxalim, INRAE, INP-ENVT, INP-EI-Purpan, Université de Toulouse 3 Paul Sabatier, Toulouse, France.
Elise Rundén-PranHealth Effects Laboratory, NILU: The Climate and Environmental Research Institute, Kjeller, Norway.
Mariam SalehANSES: French Agency for Food, Environmental and Occupational Health and Safety, Fougères Laboratory, Toxicology of Contaminants Unit, Fougères, France.
Iva SovadinováRECETOX: RECETOX, Faculty of Science, Masaryk University, Brno, Czechia.
Martina StamparDepartment of Genetic Toxicology and Cancer Biology, NIB: National Institute of Biology, Ljubljana, Slovenia.
Lea ThibolDepartment of Chemistry, RPTU: Division of Food Chemistry and Toxicology, Kaiserslautern, Germany.
Céline TomkiewiczINSERM: INSERM UMR-S 1124 T3S-Université Paris Cité, Paris, France.
Ariane VettorazziDepartment of Pharmacology and Toxicology, School of Pharmacy and Nutrition, UNAV: University of Navarra, Pamplona, Spain.
Bob Van de WaterUL-LACDR: Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.
Naouale El YamaniHealth Effects Laboratory, NILU: The Climate and Environmental Research Institute, Kjeller, Norway.
Bojana ZeguraDepartment of Genetic Toxicology and Cancer Biology, NIB: National Institute of Biology, Ljubljana, Slovenia.
Michael OelgeschlägerDepartment Experimental Toxicology and ZEBET, German Centre for the Protection of Laboratory Animals (Bf3R) and Department Food Safety, BfR: German Federal Institute for Risk Assessment, Berlin, Germany.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carcinogenic chemicals, or their metabolites, can be classified as genotoxic or non-genotoxic carcinogens (NGTxCs). Genotoxic compounds induce DNA damage, which can be detected by an established
Indexed as
NAMnew approach methodologiesNGTxCnon-genotoxic carcinogensPARC
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.