Evidence map›Paper›PMID 37492569›Full record

ArticleFrontiers in immunology2023

Plasma cells are not restricted to the CD27+ phenotype: characterization of CD27-CD43+ antibody-secreting cells.

Kris Covens, Bert Verbinnen, Britt G de Jong, Leen Moens, Greet Wuyts, Geert Verheyen, Kris Nys, Jonathan Cremer, Stijn Smulders, Rik Schrijvers and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 5 countries.

Kris CovensDepartment of Microbiology and Immunology, Clinical and Diagnostic Immunology Research Group, Leuven, Belgium.
Bert VerbinnenDepartment of Microbiology and Immunology, Clinical and Diagnostic Immunology Research Group, Leuven, Belgium.
Britt G de JongDepartment of Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
Leen MoensDepartment of Microbiology and Immunology, Clinical and Diagnostic Immunology Research Group, Leuven, Belgium.
Greet WuytsDepartment of Microbiology and Immunology, Clinical and Diagnostic Immunology Research Group, Leuven, Belgium.
Geert VerheyenBiomedical Laboratory Technology, Radius, Life Sciences and Chemistry, Thomas More Kempen, Geel, Belgium.
Kris NysGastroenterology, University Hospitals Leuven, Leuven, Belgium.
Jonathan CremerDepartment of Microbiology and Immunology, Allergy and Clinical Immunology Research Group, Leuven, Belgium.
Stijn SmuldersDepartment of Microbiology and Immunology, Clinical and Diagnostic Immunology Research Group, Leuven, Belgium.
Rik SchrijversDepartment of Microbiology and Immunology, Allergy and Clinical Immunology Research Group, Leuven, Belgium.
Andreas WeinhäuselAIT Austrian Institute of Technology GmbH, Center for Health and Bioresources, Molecular Diagnostics, Vienna, Austria.
Séverine VermeireGastroenterology, University Hospitals Leuven, Leuven, Belgium.
Patrick VerschuerenDepartment of Rheumatology, University Hospitals Leuven, Leuven, Belgium.
Ellen De LangheDepartment of Rheumatology, University Hospitals Leuven, Leuven, Belgium.
Jacques J M van DongenDepartment of Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
Menno C van ZelmDepartment of Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
Xavier BossuytDepartment of Microbiology and Immunology, Clinical and Diagnostic Immunology Research Group, Leuven, Belgium.
KU Leuven · BEErasmus MC · NLThomas More Kempen · BEAustrian Institute of Technology · ATUniversidad de Salamanca · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating antibody-secreting cells are present in the peripheral blood of healthy individuals reflecting the continued activity of the humoral immune system. Antibody-secreting cells typically express CD27. Here we describe and characterize a small population of antibody-secreting class switched CD19+CD43+ B cells that lack expression of CD27 in the peripheral blood of healthy subjects. In this study, we characterized CD27-CD43+ cells. We demonstrate that class-switched CD27-CD43+ B cells possess characteristics of conventional plasmablasts as they spontaneously secrete antibodies, are morphologically similar to antibody-secreting cells, show downregulation of B cell differentiation markers, and have a gene expression profile related to conventional plasmablasts. Despite these similarities, we observed differences in IgA and IgG subclass distribution, expression of homing markers, replication history, frequency of somatic hypermutation, immunoglobulin repertoire, gene expression related to Toll-like receptors, cytokines, and cytokine receptors, and antibody response to vaccination. Their frequency is altered in immune-mediated disorders. Conclusion: we characterized CD27-CD43+ cells as antibody-secreting cells with differences in function and homing potential as compared to conventional CD27+ antibody-secreting cells.

Indexed as

B-LymphocytesPlasma CellsAntibody-Producing CellsImmunoglobulin GPhenotypeImmunoglobulin Gantibody secreting cellsB lymphocyteCD27CD43plasmablastsomatic hypermutation

Identifiers

PMID37492569
PMCPMC10364057
OpenAlexW4383721028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.