Evidence map›Paper›PMID 37492481›Full record

ArticleFrontiers in behavioral neuroscience2023

Pre-treatment amygdala activation and habituation predict symptom change in post-traumatic stress disorder.

Cecilia A Hinojosa, Michael B VanElzakker, Navneet Kaur, Julia M Felicione, Meredith E Charney, Eric Bui, Luana Marques, Paul Summergrad, Scott L Rauch, Naomi M Simon and 1 more

Abstract read
In one paragraph

Article in Frontiers in behavioral neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Rat Models in Post-Traumatic Stress Disorder Research: Strengths, Limitations, and Implications for Translational Studies.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cecilia A HinojosaDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States.
Michael B VanElzakkerDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Navneet KaurDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Julia M FelicioneDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Meredith E CharneyDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Eric BuiNormandie Univ, University of Caen Normandy (UNICAEN), L'Institut national de la santé et de la recherche médicale (INSERM), U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NEUROPRESAGE Team, (Institut Blood and Brain @ Caen-Normandie), GIP Cyceron, Caen, France.
Luana MarquesDepartment of Psychiatry, Massachusetts General Hospital, Center for Anxiety and Traumatic Stress Disorders, Boston, MA, United States.
Paul SummergradDepartment of Psychiatry, Tufts University School of Medicine, Boston, MA, United States.
Scott L RauchDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Naomi M SimonDepartment of Psychiatry, New York University (NYU) Grossman School of Medicine, New York, NY, United States.
Lisa M ShinDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.

Funding

ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 1999 to 2011
$16.4M
NCRR NIH HHS P41 RR014075
6 · The paper itself

Abstract

Trauma-focused psychotherapy approaches are the first-line treatment option for post-traumatic stress disorder (PTSD); however, up to a third of patients remain symptomatic even after completion of the treatment. Predicting which patients will respond to a given treatment option would support personalized treatments and improve the efficiency of healthcare systems. Although previous neuroimaging studies have examined possible pre-treatment predictors of response to treatment, the findings have been somewhat inconsistent, and no other study has examined habituation to stimuli as a predictor. In this study, 16 treatment-seeking adults (M

Indexed as

biomarkersfMRIpost-traumatic stress disorderprolonged exposure therapysymptom change

Identifiers

PMID37492481
PMCPMC10363634

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.