Evidence map›Paper›PMID 37492374›Full record

ArticleNAR cancer2023

An integrated genomic approach identifies follistatin as a target of the p63-epidermal growth factor receptor oncogenic network in head and neck squamous cell carcinoma.

Akinsola Oyelakin, Jennifer Sosa, Kasturi Bala Nayak, Alexandra Glathar, Christian Gluck, Isha Sethi, Maria Tsompana, Norma Nowak, Michael Buck, Rose-Anne Romano and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NAR cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Differential gene expression profile inJournal of oral biology and craniofacial research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Akinsola OyelakinDepartment of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY, USA.ORCID https://orcid.org/0000-0003-0607-6631
Jennifer SosaDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
Kasturi Bala NayakDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
Alexandra GlatharDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
Christian GluckDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
Isha SethiDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
Maria TsompanaDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
Norma NowakDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
Michael BuckDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.ORCID https://orcid.org/0000-0001-5320-3678
Rose-Anne RomanoDepartment of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY, USA.
Satrajit SinhaDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.ORCID https://orcid.org/0000-0002-9574-4576
University at Buffalo, State University of New York · US

Funding

Enabling Access to Cutting-Edge Biomedical and Behavioral ScienceR25GM095459 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DUBOCOVICH, MARGARITA L · 2012 to 2021
$4.4M
Advanced Training in Oral BiologyT32DE023526 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Stefan Hans-Klaus Ruhl · 2013 to 2026
$3.7M
Mentoring For Success: Teaching Faculty Fundamental Skills For Attracting, Admitting and Developing StudentsT32GM144920 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Margarita L Dubocovich · 2022 to 2026
$3.1M
A high-throughput, comprehensive, and quantitative approach for measuring nucleosome-protein bindingR01GM132199 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BUCK, MICHAEL JOSEPH · 2019 to 2022
$1.4M
Molecular analysis of the oncogenic role of p63 in the development and progression of oral squamous cell carcinomasF31DE028480 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI OYELAKIN, AKINSOLA AYOMIKUN · 2019 to 2020
$53k
NIDCR NIH HHS F31 DE028480NIDCR NIH HHS T32 DE023526NIGMS NIH HHS R01 GM132199NIGMS NIH HHS R25 GM095459NIGMS NIH HHS T32 GM144920
6 · The paper itself

Abstract

Although numerous putative oncogenes have been associated with the etiology of head and neck squamous cell carcinoma (HNSCC), the mechanisms by which these oncogenes and their downstream targets mediate tumor progression have not been fully elucidated. We performed an integrative analysis to identify a crucial set of targets of the oncogenic transcription factor p63 that are common across multiple transcriptomic datasets obtained from HNSCC patients, and representative cell line models. Notably, our analysis revealed

Identifiers

PMID37492374
PMCPMC10365026
OpenAlexW4385227055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.