ArticleFrontiers in cardiovascular medicine2023
The interaction between uric acid and high-density lipoprotein cholesterol on the prognosis of patients with acute myocardial infarction.
Article in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- The predictive value of TC/HDL ratio in patients with acute myocardial infarction undergoing PCI.BMC cardiovascular disorders · 2026Article
- A comprehensive study on the uric acid to high-density cholesterol ratio influencing cardiometabolic-based chronic disease in China.Frontiers in nutrition · 2026Article
- Relationship of admission uric acid to high density lipoprotein cholesterol ratio with unfavorable prognosis among acute ischemic stroke patients.Lipids in health and disease · 2025Article
- The uric acid to high density lipoprotein cholesterol ratio as a new indicator for predicting coronary slow flow phenomenon.BMC cardiovascular disorders · 2025Article
- The combined association of the neutrophil percentage-to-albumin ratio (NPAR) and the uric acid-to-high-density lipoprotein cholesterol ratio (UHR) with adverse cardiac events in patients with chronic heart failure: a retrospective cohort study.Lipids in health and disease · 2025Article
- Uric Acid to HDL-C Ratio as a Marker of Coronary Artery Disease Severity in Non-ST-Elevation Myocardial Infarction Patients.Acta Cardiologica Sinica · 2025Article
- The ratio of serum uric acid to high-density lipoprotein cholesterol as a predictor for frailty prevalence and mortality in the elderly U.S. adults.Lipids in health and disease · 2025Article
- Diabetes mediates the association between uric acid to high-density lipoprotein cholesterol ratio and abdominal aortic calcification: a cross-sectional study.Scientific reports · 2025Article
- The association between serum uric acid to high density lipoprotein ratio and cardiometabolic-related risk in adults with obesity.Endocrine · 2025Article
- Association Between the Uric Acid to High-Density Lipoprotein Cholesterol Ratio and Residual Risk for Coronary Artery Disease.Cardiovascular toxicology · 2025Observational
- Association between the uric acid-to-HDL-cholesterol ratio (UHR) and the risk of cardiovascular disease and dyslipidemia: a population-based study.Lipids in health and disease · 2025Article
- Article
- Predictive value of TG/HDL-C and GFR-adjusted uric acid levels on cardiovascular mortality: the URRAH study.Lipids in health and disease · 2025Article
- Impact of serum uric acid to high-density lipoprotein cholesterol ratio on short-term outcomes in acute decompensated heart failure: a cohort study in Jiangxi Province, China.Frontiers in endocrinology · 2025Article
- The correlation between the uric acid to high-density lipoprotein cholesterol ratio and stroke.Frontiers in medicine · 2025Article
- Mortality risk prediction of uric acid to high-density lipoprotein cholesterol ratio in community residents: a cohort study.BMJ nutrition, prevention & health · 2025Article
- Relationship between uric acid to HDL ratio and extent and severity of coronary artery disease.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2024Article
- Predictive value of the serum uric acid to high-density lipoprotein cholesterol ratio for culprit plaques in patients with acute coronary syndrome.BMC cardiovascular disorders · 2024Article
- Associations of Serum Uric Acid to High-Density Lipoprotein Cholesterol Ratio with Trunk Fat Mass and Visceral Fat Accumulation.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Association of serum uric acid to high-density lipoprotein cholesterol ratio with all-cause and cardiovascular mortality in patients with diabetes or prediabetes: a prospective cohort study.Frontiers in endocrinology · 2024Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The significance of uric acid (UA) and high-density lipoprotein cholesterol (HDL-C) in the prognosis of acute myocardial infarction (AMI) remains controversial. This study investigated the effect of the interaction between UA and HDL-C on the prognosis of patients with AMI. Methods: In total, 480 patients with AMI were included in this study. Baseline and follow-up data were collected, and the primary endpoint was major adverse cardiovascular events (MACE). The secondary endpoint was all-cause death. Both additive and multiplicative interactions were calculated to evaluate their interaction with prognosis. Then, the impact of UA and HDL-C ratio (UHR) on prognosis was assessed. Results: Over a median follow-up period of 41 (30,46) months, 136 (28.3%) MACEs, and 44 (9.2%) deaths were recorded. There was a positive additive interaction between UA and HDL-C for MACEs. The attributable proportion (AP) showed that 46% of the estimated effect (MACE in patients) was attributable to this interaction. The synergy index (SI) was 2.04 (1.07,3.88) for MACE, indicating that the risk for patients presenting with both risk factors was greater than the sum of the risk factors alone. Multivariate Cox regression analysis revealed that UHR independently predicted MACEs and mortality. Kaplan-Meier survival curves according to tertiles of UHR showed statistically significant differences in MACE (log-rank test, Conclusion: The coexistence of high UA and low HDL-C has a synergistic effect and provides further information for risk stratification of patients with AMI. UHR is a simple and easily available prognostic indicator independent of traditional risk factors.
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