ArticleCell genomics2023
150 risk variants for diverticular disease of intestine prioritize cell types and enable polygenic prediction of disease susceptibility.
Article in Cell genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- A Genome-Wide Meta-Analysis of Functional Dyspepsia in 1,168,899 Individuals Implicates Immune Pathways in Disease Susceptibility.Neurogastroenterology and motility · 2026Pooled it
- Pooled it
- Pooled it
- The genetics of fibromyalgia and its relationships to psychiatric and medical traits.Nature communications · 2026Article
- Utility of Colonoscopy After Acute Colonic Diverticulitis.Diagnostics (Basel, Switzerland) · 2026Review
- Genetic Risk, Healthy Lifestyle, and Risk Stratification for Diverticulitis.Journal of the American College of Surgeons · 2026Article
- Genome-wide association study reveals acute mountain sickness susceptibility in Chinese population.Molecular genetics and genomics : MGG · 2026Article
- Plasma Proteomic Signatures for Diverticulitis Risk Stratification.The Journal of surgical research · 2026Article
- Novel polygenic risk score associates with diverticulitis in a multi-institutional, ancestrally diverse cohort.Scientific reports · 2025Article
- Article
- Multiancestry transferability of a polygenic risk score for diverticulitis.BMJ open gastroenterology · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
We conducted a genome-wide association study (GWAS) analysis of diverticular disease (DivD) of intestine within 724,372 individuals and identified 150 independent genome-wide significant DNA variants. Integration of the GWAS results with human gut single-cell RNA sequencing data implicated gut myocyte, mesothelial and stromal cells, and enteric neurons and glia in DivD development. Ninety-five genes were prioritized based on multiple lines of evidence, including
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.