Evidence map›Paper›PMID 37491918›Full record

ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2023

Functional interferon-epsilon gene polymorphisms and sexually transmitted infections of the endometrium.

Brandie DePaoli Taylor, Michael F Criscitiello, Fuller W Bazer, Lauren S Richardson, Akaninyene Noah, Catherine L Haggerty

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Brandie DePaoli TaylorDepartment of Obstetrics and Gynecology, Division of Basic Science and Translational Research, University of Texas Medical Branch, Galveston, Texas, USA.
Michael F CriscitielloComparative Immunogenetics Laboratory, Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Fuller W BazerDepartment of Animal Science, Texas A&M University, College Station, Texas, USA.
Lauren S RichardsonDepartment of Obstetrics and Gynecology, Division of Basic Science and Translational Research, University of Texas Medical Branch, Galveston, Texas, USA.
Akaninyene NoahDepartment of Obstetrics and Gynecology, Division of Basic Science and Translational Research, University of Texas Medical Branch, Galveston, Texas, USA.
Catherine L HaggertyDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
The University of Texas Medical Branch at Galveston · USTexas A&M University · USUniversity of Pittsburgh · US

Funding

UTMB WOMEN'S HEALTH RESEARCH SCHOLARS PROGRAMK12HD052023 · NICHD · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI BERENSON, ABBEY B · 2005 to 2023
$8.1M
UTMB Women's Health Research Scholars ProgramK12AR084228 · NIAMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI ABBEY B BERENSON · 2023 to 2026
$2.7M
Mycoplasma Genitalium and Pelvic Inflammatory DiseaseR01AI067661 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HAGGERTY, CATHERINE L · 2005 to 2007
$978k
Evaluation of Novel Interferon Epsilon across Human PregnancyR21AI140178 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI TAYLOR, BRANDIE DEPAOLI · 2018 to 2019
$420k
Mycoplasma genitalium and pelvic inflammatory diseaseR56AI067661 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HAGGERTY, CATHERINE L · 2010 to 2010
$337k
AHRQ HHS R01 HS008358NIAID NIH HHS R01 AI067661NIAID NIH HHS R21 AI140178NIAID NIH HHS R56 AI067661NIAMS NIH HHS K12 AR084228NICHD NIH HHS K12 HD052023
6 · The paper itself

Abstract

problemInterferon-epsilon (IFNε) is the only type I IFN constitutively expressed in the female reproductive tract and fluctuates across the menstrual cycle in humans. Mouse models show that IFNε protects against Chlamydia trachomatis, Herpes Simplex Virus, HIV, and Zika in mice, but human studies are limited. Bacterial sexually transmitted infections (STI) can ascend to the upper genital tract and cause pelvic inflammatory disease (PID) and subsequent infertility. However, the host immunological mechanisms that play a role in the ascension and infection of the endometrium in individuals with clinically suspected PID are not elucidated. METHOD OF STUDY: This pilot investigation determined if IFNε gene variants are associated with bacterial vaginosis (BV) and endometrial infection with C. trachomatis, Neisseria gonorrhoeae, and Mycoplasma genitalium using biospecimens from 154 self-report Black individuals who participated in the PID Evaluation and Clinical Health (PEACH) study.

resultsThe T allele for rs2039381 was associated with endometrial STI infection (OR 2.7, 95% CI: 1.0-7.1) and the C allele for rs1125488 was inversely associated with BV (OR: .2, 95% CI: .05-.8).

conclusionsFew studies have examined IFNε gene variants, our study raises the possibility that IFNε gene variants may be a potential host contributor to STI pathogenesis.

Indexed as

Chlamydia InfectionsMycoplasma InfectionsPelvic Inflammatory DiseaseSexually Transmitted DiseasesVaginosis, BacterialZika VirusZika Virus InfectionAnimalsChlamydia trachomatisEndometriumFemaleHumansInterferonsMiceInterferonsendometritisgeneticsinterferonssexually transmitted diseases

Identifiers

PMID37491918
PMCPMC10793201
OpenAlexW4384928736

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.