ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2023
Management Strategies Based on Multi-Modality Neuromonitoring in Severe Traumatic Brain Injury.
Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Intracranial multimodal monitoring in neurocritical care (Neurocore-iMMM): an open, decentralized consensus.Critical care (London, England) · 2024Guideline
- Perioperative cerebrospinal fluid lactate and glucose changes following intracranial surgery: A prospective observational cohort study.Medicine · 2026Observational
- Advances in Multimodality Monitoring in Traumatic Brain Injury.Current neurology and neuroscience reports · 2026Review
- Depth-sensitive cerebral blood flow and low-frequency oscillations for consciousness assessment using time-domain diffuse correlation spectroscopy.Neurophotonics · 2026Article
- Depth-sensitive assessment of cerebral blood flow and low-frequency oscillations after traumatic brain injury in mice using time-domain diffuse correlation spectroscopy.Neurophotonics · 2026Article
- The border-associated macrophage marker MRC1 contributes to an early neuroprotective inflammatory response to traumatic brain injury in mice.Acta neuropathologica communications · 2025Article
- The Role of Intraoperative Neurophysiological Monitoring in Intracranial Cavernous Malformation Surgery: A Narrative Review.Iranian journal of medical sciences · 2025Review
- A Comprehensive Review of Fluid Resuscitation Strategies in Traumatic Brain Injury.Journal of clinical medicine · 2025Review
- Unlocking therapeutic potential in traumatic brain injury: exploring microenvironmental targets, signaling pathways and translational hurdles.Inflammopharmacology · 2025Review
- Evolving concepts in intracranial pressure monitoring - from traditional monitoring to precision medicine.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Optical approaches for neurocritical care: Toward non-invasive recording of cerebral physiology in acute brain injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Construction of nomogram model for early death risk in patients with severe traumatic brain injury.Frontiers in neurology · 2025Article
- Fully Automated and AI-Assisted Optical Fiber Sensing System for Multiplexed and Continuous Brain Monitoring.ACS sensors · 2024Article
- How to Define and Meet Blood Pressure Targets After Traumatic Brain Injury: A Narrative Review.Neurocritical care · 2024Review
- Further support for the intracranial compartmental syndrome concept.Critical care (London, England) · 2024Article
- Clinical Impact of Standardized Interpretation and Reporting of Multimodality Neuromonitoring Data.Critical care explorations · 2024Observational
- Current state of neuroprotective therapy using antibiotics in human traumatic brain injury and animal models.BMC neuroscience · 2024Review
- Global traumatic brain injury intracranial pressure: from monitoring to surgical decision.Frontiers in neurology · 2024Review
- Oral administration of lysozyme protects against injury of ileum via modulating gut microbiota dysbiosis after severe traumatic brain injury.Frontiers in cellular and infection microbiology · 2024Article
- Pharmacotherapy for Traumatic Brain Injury: The Next Generation of Clinical Trials.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Secondary brain injury after neurotrauma is comprised of a host of distinct, potentially concurrent and interacting mechanisms that may exacerbate primary brain insult. Multimodality neuromonitoring is a method of measuring multiple aspects of the brain in order to understand the signatures of these different pathomechanisms and to detect, treat, or prevent potentially reversible secondary brain injuries. The most studied invasive parameters include intracranial pressure (ICP), cerebral perfusion pressure (CPP), autoregulatory indices, brain tissue partial oxygen tension, and tissue energy and metabolism measures such as the lactate pyruvate ratio. Understanding the local metabolic state of brain tissue in order to infer pathology and develop appropriate management strategies is an area of active investigation. Several clinical trials are underway to define the role of brain tissue oxygenation monitoring and electrocorticography in conjunction with other multimodal neuromonitoring information, including ICP and CPP monitoring. Identifying an optimal CPP to guide individualized management of blood pressure and ICP has been shown to be feasible, but definitive clinical trial evidence is still needed. Future work is still needed to define and clinically correlate patterns that emerge from integrated measurements of metabolism, pressure, flow, oxygenation, and electrophysiology. Pathophysiologic targets and precise critical care management strategies to address their underlying causes promise to mitigate secondary injuries and hold the potential to improve patient outcome. Advancements in clinical trial design are poised to establish new standards for the use of multimodality neuromonitoring to guide individualized clinical care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.