ArticleAddiction (Abingdon, England)2023
Joint effects of substance use disorders and recent substance use on HIV viral non-suppression among people engaged in HIV care in an urban clinic, 2014-2019.
Article in Addiction (Abingdon, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Association Between Housing Instability and HIV Care Outcomes Among People With HIV in the United States.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- Perceived disabling physical pain and suicidal ideation in aging people living with HIV cured of hepatitis C: A multi-center survey in France (ANRS CO13 HEPAVIH).HIV medicine · 2026Article
- Age and Race Disparities in Viral Suppression and the Moderating Effect of Substance Use Among Men Who Have Sex with Men Living with HIV.The journal of behavioral health services & research · 2026Article
- The effect of antidepressant treatment on viral suppression among people with HIV diagnosed with depression in an urban clinic.AIDS (London, England) · 2025Observational
- Measuring time in buprenorphine treatment stages among people with HIV and opioid use disorder by retention definition and its association with cocaine and hazardous alcohol use.Addiction science & clinical practice · 2023Article
- Using Incentivization as a Strategy to Improve Implementation of a Motivational Interviewing Brief Intervention for Substance Use Disorders in HIV Settings: Results of a 26-Site Parallel Groups Cluster-Randomized Type-3 Hybrid Trial.Implementation research and practiceArticle
- Supporting integration of substance use interventions in HIV service organizations: Assessing the fit of 10 strategies for AIDS Education and Training Centers to use.Implementation research and practiceArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
aimsTo estimate the joint effects of substance use disorder (SUD) and recent substance use on human immunodeficiency virus (HIV) non-suppression.
designRetrospective clinical cohort study with repeated observations within individuals.
settingBaltimore, Maryland, United States.
participants1881 patients contributed 10 794 observations. MEASUREMENTS: The primary independent variable was the combination of history of SUD and recent substance use. History of SUD was defined as any prior International Classification of Diseases 9/10 code for cocaine or opioid disorder. Recent substance use was defined as the self-report of cocaine or non-prescribed opioid use on the National Institute of Drug Abuse-modified Alcohol, Smoking and Substance Involvement Screening Test or clinician-documented cocaine or opioid use abstracted from the medical record. The outcome was viral non-suppression, defined as HIV RNA >200 copies/mL on the first viral load measurement within 1 year subsequent to each observation of substance use. We adjusted for birth sex, Black race, age, HIV acquisition risk factors, years in care and CD4 cell count. In secondary analyses, we also adjusted for depressive, anxiety and panic symptoms, cannabis use and cannabis use disorder.
findingsOn their first observation, 31% of patients had a history of an SUD and 18% had recent substance use. Relative to no history of SUD and no recent substance use, the 1-year fully adjusted risk difference (RD) for viral non-suppression associated with cocaine and opioid use disorder and recent substance use was 7.7% (95% CI = 5.3%-10.0%), the RD was 5.5% (95% CI = 1.2%-9.7%) for history of cocaine use disorder without recent substance use, and the RD was 4.6% (95% CI = 2.7%-6.5%) for recent substance use without a SUD.
conclusionsSubstance use and substance use disorders appear to be highly prevalent among, and independently associated with, viral non-suppression among people with HIV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.