ArticleInternational journal of obesity (2005)2023
Central obesity and its association with retinal age gap: insights from the UK Biobank study.
Article in International journal of obesity (2005), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Reduction of glycation stress as a geroscience intervention: protocol for a pilot RCT in postmenopausal women.npj aging · 2026Article
- Modifiable risk factors associated with increased retinal age gap in an Australian population.GeroScience · 2026Article
- Prevalence and correlates of overweight and obesity in patients with major depression accompanied by abnormal TSH levels.BMC psychiatry · 2025Article
- Artificial intelligence-derived retinal age gap as a marker for reproductive aging in women.NPJ digital medicine · 2025Article
- Article
- Estimating biological age from retinal imaging: a scoping review.BMJ open ophthalmology · 2024Article
- Association between biological aging and diabetic retinopathy.Scientific reports · 2024Article
- Automated Retinal Vessel Analysis Based on Fundus Photographs as a Predictor for Non-Ophthalmic Diseases-Evolution and Perspectives.Journal of personalized medicine · 2023Review
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Authors and funding
6 authors.
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Abstract
backgroundConflicting evidence exists on the association between ageing and obesity. Retinal age derived from fundus images has been validated as a novel biomarker of ageing. In this study, we aim to investigate the association between different anthropometric phenotypes based on body mass index (BMI) and waist circumference (WC) and the retinal age gap (retinal age minus chronological age).
methodsA total of 35,550 participants with BMI, WC and qualified retinal imaging data available were included to investigate the association between anthropometric groups and retinal ageing. Participants were stratified into 7 different body composition groups based on BMI and WC (Normal-weight/Normal WC, Overweight/Normal WC, Mild obesity/Normal WC, Normal-weight/High WC, Overweight/High WC, Mild obesity/High WC, and Severe obesity/High WC). Linear regression and logistic regression models were fitted to investigate the association between the seven anthropometric groups and retinal age gap as continuous and categorical outcomes, respectively.
resultsA total of 35,550 participants (55.6% females) with a mean age 56.8 ± 8.04 years were included in the study. Individuals in the Overweight/High WC, Mild obesity/High WC and Severe obesity/High WC groups were associated with an increase in the retinal age gap, compared with those in the Normal Weight/Normal WC group (β = 0.264, 95% CI: 0.105-0.424, P =0.001; β = 0.226, 95% CI: 0.082-0.371, P = 0.002; β = 0.273, 95% CI: 0.081-0.465, P = 0.005; respectively) in fully adjusted models. Similar findings were noted in the association between the anthropometric groups and retinal ageing process as a categorical outcome.
conclusionA significant positive association exists between central obesity and accelerated ageing indexed by retinal age gaps, highlighting the significance of maintaining a healthy body shape.
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