Evidence map›Paper›PMID 37491264›Full record

Trial reportTrials2023

Pragmatic cluster-randomized trial of home-based preventive treatment for TB in Ethiopia and South Africa (CHIP-TB).

Akash Malhotra, Bareng Aletta Sanny Nonyane, Evan Shirey, Christiaan Mulder, Piotr Hippner, Fiseha Mulatu, Andani Ratshinanga, Petros Mitiku, Silvia Cohn, Gideon Conradie and 9 more

Registry-linked trialAbstract readRandomized Controlled TrialPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04369326 (Community Initiated Preventive Therapy for TB), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04369326 nacompletednot on this map

Community Initiated Preventive Therapy for TB (CHIP-TB Trial)

TypeinterventionalSponsorJohns Hopkins UniversityRan2021 to 2023Enrolled1,168ConditionsTuberculosisArmsCommunity-Based TPT Initiation
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Akash MalhotraDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Bareng Aletta Sanny NonyaneDepartment of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Evan ShireyDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Christiaan MulderDepartment of TB Elimination and Health System Innovations, KNCV Tuberculosis Foundation, The Hague, The Netherlands.
Piotr HippnerThe Aurum Institute, Parktown, Johannesburg, South Africa.
Fiseha MulatuKNCV Tuberculosis Foundation, Addis Ababa, Ethiopia.
Andani RatshinangaThe Aurum Institute, Parktown, Johannesburg, South Africa.
Petros MitikuKNCV Tuberculosis Foundation, Addis Ababa, Ethiopia.
Silvia CohnDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gideon ConradieThe Aurum Institute, Parktown, Johannesburg, South Africa.
Violet ChihotaThe Aurum Institute, Parktown, Johannesburg, South Africa.
Richard E ChaissonDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Gavin J ChurchyardThe Aurum Institute, Parktown, Johannesburg, South Africa.
Jonathan GolubDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
David DowdyDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Hojoon SohnDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Salome CharalambousThe Aurum Institute, Parktown, Johannesburg, South Africa.
Ahmed BedruKNCV Tuberculosis Foundation, Addis Ababa, Ethiopia.
Nicole Salazar-AustinDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. nsalaza1@jhmi.edu.ORCID http://orcid.org/0000-0002-9875-9319

Funding

Research Training in Pediatric Infectious DiseasesT32AI052071 · NIAID · JOHNS HOPKINS UNIVERSITY · PI AARON M MILSTONE · 2002 to 2026
$5.2M
NIAID NIH HHS T32 AI052071
6 · The paper itself

Abstract

backgroundEach year, 1 million children develop TB resulting in over 200,000 child deaths. TB preventive treatment (TPT) is highly effective in preventing TB but remains poorly implemented for household child contacts. Home-based child contact management and TPT services may improve access to care. In this study, we aim to evaluate the effectiveness and cost-effectiveness of home-based contact management with TPT initiation in two TB high-burden African countries, Ethiopia and South Africa.

methodsThis pragmatic cluster randomized trial compares home-based versus facility-based care delivery models for contact management. Thirty-six clinics with decentralized TB services (18 in Ethiopia and 18 in South Africa) were randomized in a 1:1 ratio to conduct either home-based or facility-based contact management. The study will attempt to enroll all eligible close child contacts of infectious drug-sensitive TB index patients diagnosed and treated for TB by one of the study clinics. Child TB contact management, including contact tracing, child evaluation, and TPT initiation and follow-up, will take place in the child's home for the intervention arm and at the clinic for the control arm. The primary outcome is the cluster-level ratio of the number of household child contacts less than 15 years of age in Ethiopia and less than 5 years of age in South Africa initiated on TPT per index patient, comparing the intervention to the control arm. Secondary outcomes include child contact identification and the TB prevention continuum of care. Other implementation outcomes include acceptability, feasibility, fidelity, cost, and cost-effectiveness of the intervention. DISCUSSION: This implementation research trial will determine whether home-based contact management identifies and initiates more household child contacts on TPT than facility-based contact management.

trial registrationNCT04369326 . Registered on April 30, 2020.

Indexed as

TuberculosisAmbulatory Care FacilitiesChildChild, PreschoolClinical ProtocolsContact TracingEthiopiaHumansSouth AfricaContact investigationEthiopiaHousehold contact managementPediatric TBPragmatic implementation trialSouth AfricaTB preventive treatmentTPTTuberculosis

Identifiers

PMID37491264
PMCPMC10367260

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.