ArticleProceedings of the National Academy of Sciences of the United States of America2023
Identification of a β-arrestin-biased negative allosteric modulator for the β
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
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Who cites it
18 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Uncoupling of the allosteric signalling network in the βNature communications · 2026Article
- Agonist-specific conformational dynamics at the βBritish journal of pharmacology · 2026Article
- Biased signaling of β2-adrenergic receptor in physiological and pathological states.Cellular & molecular biology letters · 2026Review
- Precision Aptamers Against a Native GPCR through Ligand-Guided Selection.bioRxiv : the preprint server for biology · 2026Article
- Qualitative beta-2-adrenoceptor signaling in the regulation of human airway epithelia mucin and cytokine production.Respiratory research · 2026Article
- Biased Allosteric Modulation in GPCR Drug Discovery.Handbook of experimental pharmacology · 2026Review
- Structural Perspectives on Biased Allostery of GPCR Signaling.Handbook of experimental pharmacology · 2026Review
- A biased allosteric modulator functions as a molecular glue to induce βResearch square · 2025Article
- A biased allosteric modulator functions as a molecular glue to induce βbioRxiv : the preprint server for biology · 2025Article
- Biased Orthosteric Agonism and Allosteric Modulation: Emerging Strategies for Developing New Class of β-Agonists for Obstructive Airway Diseases.American journal of respiratory cell and molecular biology · 2025Review
- Channeling Relaxation through Multiple Means: TMEM16A Antagonism for Asthma.American journal of respiratory cell and molecular biology · 2025Article
- Implication of Central βArchiv der Pharmazie · 2025Review
- Integrative residue-intuitive machine learning and MD Approach to Unveil Allosteric Site and Mechanism for β2AR.Nature communications · 2024Article
- The ufmylation cascade controls COPII recruitment, anterograde transport, and sorting of nascent GPCRs at ER.Science advances · 2024Article
- G Protein-Coupled Receptors: A Century of Research and Discovery.Circulation research · 2024Review
- G protein-coupled receptors (GPCRs): advances in structures, mechanisms, and drug discovery.Signal transduction and targeted therapy · 2024Review
- Computational Modeling and Characterization of Peptides Derived from Nanobody Complementary-Determining Region 2 (CDR2) Targeting Active-State Conformation of the βBiomolecules · 2024Article
Corrections and comments
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Authors and funding
20 authors at 4 institutions in 1 country.
Michael IppolitoDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107.
Francesco De PascaliDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107.
Nathan HopfingerDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107.
Konstantin E KomolovDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107.ORCID 0000-0001-6799-4626
Daniela LaurinavichyuteDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107.
Poli Adi Narayana ReddyThe Wistar Institute Philadelphia, Philadelphia, PA 19104.
Leon A SakkalDepartment of Pharmaceutical Sciences, College of Pharmacy, Thomas Jefferson University, Philadelphia, PA 19107.ORCID 0000-0002-8164-6772
Kyle Z RajkowskiDepartment of Pharmaceutical Sciences, College of Pharmacy, Thomas Jefferson University, Philadelphia, PA 19107.
Ajay P NayakCenter for Translational Medicine, Department of Medicine, and Jane and Leonard Korman Respiratory Institute, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107.ORCID 0000-0003-3437-0096
Justin LeeRutgers Institute for Translational Medicine and Science, New Brunswick, NJ 08901.ORCID 0000-0002-3153-3075
Jordan LeeRutgers Institute for Translational Medicine and Science, New Brunswick, NJ 08901.
Gaoyuan CaoRutgers Institute for Translational Medicine and Science, New Brunswick, NJ 08901.ORCID 0000-0001-8308-7401
Preston S DonoverLankenau Institute for Medical Research, Wynnewood, PA 19096.ORCID 0009-0003-5627-0560
Melvin ReichmanLankenau Institute for Medical Research, Wynnewood, PA 19096.ORCID 0000-0001-8833-3421
Steven S AnRutgers Institute for Translational Medicine and Science, New Brunswick, NJ 08901.ORCID 0000-0003-4723-1888
Joseph M SalvinoThe Wistar Institute Philadelphia, Philadelphia, PA 19104.ORCID 0000-0002-2184-5980
Raymond B PennCenter for Translational Medicine, Department of Medicine, and Jane and Leonard Korman Respiratory Institute, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107.
Roger S ArmenDepartment of Pharmaceutical Sciences, College of Pharmacy, Thomas Jefferson University, Philadelphia, PA 19107.
Charles P ScottDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107.ORCID 0000-0002-3191-4839
Jeffrey L BenovicDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107.
Thomas Jefferson University · USRutgers, The State University of New Jersey · USLankenau Institute for Medical Research · USThe Wistar Institute · US
Funding
Project 4 - OGR1- and TSPO- dependent mechanisms mediated by benzodiazepines affecting ASM contractionP01HL114471 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BENOVIC, JEFFREY L · 2013 to 2023
$23.9MTRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4MG Protein-Coupled Receptor Signaling in Airway Smooth MuR01HL058506 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RAYMOND B. PENN · 2001 to 2026
$9.3MNovel Biased Beta2-AR Ligands as Asthma TherapeuticsR01AI161296 · NIAID · DUKE UNIVERSITY · PI CHU, HONG W, DICKEY, BURTON F · 2021 to 2025
$3.2MRegulation of G protein-coupled receptor signaling and traffickingR35GM122541 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI BENOVIC, JEFFREY L · 2017 to 2021
$2.5MCharacterization of beta-arrestin-biased beta 2-adrenergic receptor signaling in cardiovascular functionR01HL136219 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI BENOVIC, JEFFREY L, TILLEY, DOUGLAS · 2017 to 2020
$2.5MStructural and dynamic analysis of GRK interaction with G protein-coupled receptorsR01HL142310 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI BENOVIC, JEFFREY L · 2018 to 2021
$2.1MMitochondrial translocator protein: a target for bronchodilationR01HL153602 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI NAYAK, AJAY · 2021 to 2025
$2.0MTraining Program in Cellular, Biochemical, and Molecular SciencesT32GM100836 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI BENOVIC, JEFFREY L · 2012 to 2016
$809kCharacterization and Development of Gs-biased ligands of Beta2-Adrenergic ReceptorF31HL139104 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI IPPOLITO, MICHAEL · 2018 to 2019
$90kNHLBI NIH HHS F31 HL139104NHLBI NIH HHS P01 HL114471NHLBI NIH HHS R01 HL058506NHLBI NIH HHS R01 HL136219NHLBI NIH HHS R01 HL142310NHLBI NIH HHS R01 HL153602NIAID NIH HHS R01 AI161296NIEHS NIH HHS T32 ES007148NIGMS NIH HHS R35 GM122541NIGMS NIH HHS T32 GM100836
Abstract
Catecholamine-stimulated β
Indexed as
ArrestinSignal Transductionbeta-Arrestin 1beta-ArrestinsReceptors, AdrenergicReceptors, Adrenergic, beta-2Arrestinbeta-Arrestin 1beta-ArrestinsReceptors, AdrenergicReceptors, Adrenergic, beta-2asthmabiased signalingcell signalingG protein–coupled receptornegative allosteric modulator
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.