ArticleProceedings of the National Academy of Sciences of the United States of America2023
Fast protein folding is governed by memory-dependent friction.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 44 citations in OpenAlex.
- Hierarchical friction memory leads to subdiffusive configurational dynamics of fast-folding proteins.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Static and dynamic rough energy landscapes can lead to identical diffusivity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Subdiffusion from competition between multi-exponential friction memory and energy barriers.The European physical journal. E, Soft matter · 2025Article
- Non-Markovian equilibrium and non-equilibrium barrier-crossing kinetics in asymmetric double-well potentials.The European physical journal. E, Soft matter · 2025Article
- Nonequilibrium relaxation exponentially delays the onset of quantum diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Hydrogen bonding heterogeneity correlates with protein folding transition state passage time as revealed by data sonification.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The Potential of Neural Network Potentials.ACS physical chemistry Au · 2024Review
- Cell migration: Beyond Brownian motion.Biophysical journal · 2024Article
- The role of memory-dependent friction and solvent viscosity in isomerization kinetics in viscogenic media.Nature communications · 2024Article
- Accurate Memory Kernel Extraction from Discretized Time-Series Data.Journal of chemical theory and computation · 2024Article
- Integrative generalized master equation: A method to study long-timescale biomolecular dynamics via the integrals of memory kernels.The Journal of chemical physics · 2023Article
- Pair-Reaction Dynamics in Water: Competition of Memory, Potential Shape, and Inertial Effects.The journal of physical chemistry. B · 2022Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When described by a low-dimensional reaction coordinate, the folding rates of most proteins are determined by a subtle interplay between free-energy barriers, which separate folded and unfolded states, and friction. While it is commonplace to extract free-energy profiles from molecular trajectories, a direct evaluation of friction is far more elusive and typically relies on fits of measured reaction rates to memoryless reaction-rate theories. Here, using memory-kernel extraction methods founded on a generalized Langevin equation (GLE) formalism, we directly calculate the time-dependent friction acting on the fraction of native contacts reaction coordinate
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