Evidence map›Paper›PMID 37490492›Full record

ArticleEuropean journal of immunology2023

Multifunctional cytokine production marks influenza A virus-specific CD4 T cells with high expression of survival molecules.

Lotus M Westerhof, Jonathan Noonan, Kerrie E Hargrave, Elizabeth T Chimbayo, Zhiling Cheng, Thomas Purnell, Mark R Jackson, Nicholas Borcherding, Megan K L MacLeod

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Lotus M WesterhofSchool of Infection and Immunity, University of Glasgow, Glasgow, UK.
Jonathan NoonanBaker Heart and Diabetes Institute & Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, Australia.
Kerrie E HargraveSchool of Infection and Immunity, University of Glasgow, Glasgow, UK.
Elizabeth T ChimbayoSchool of Infection and Immunity, University of Glasgow, Glasgow, UK.
Zhiling ChengSchool of Infection and Immunity, University of Glasgow, Glasgow, UK.
Thomas PurnellSchool of Infection and Immunity, University of Glasgow, Glasgow, UK.
Mark R JacksonSchool of Cancer Sciences, University of Glasgow, Glasgow, UK.
Nicholas BorcherdingDepartment of Pathology and Immunology, Washington University, St Louis, Missouri, USA.
Megan K L MacLeodSchool of Infection and Immunity, University of Glasgow, Glasgow, UK.ORCID 0000-0003-1843-8580
University of Glasgow · GBBaker Heart and Diabetes Institute · AUUniversity of Liverpool · GBWashington University in St. Louis · US

Funding

Wellcome TrustWellcome Trust 210703/Z/18/Z
6 · The paper itself

Abstract

Cytokine production by memory T cells is a key mechanism of T cell mediated protection. However, we have limited understanding of the persistence of cytokine producing T cells during memory cell maintenance and secondary responses. We interrogated antigen-specific CD4 T cells using a mouse influenza A virus infection model. Although CD4 T cells detected using MHCII tetramers declined in lymphoid and non-lymphoid organs, we found similar numbers of cytokine

Indexed as

CD4-Positive T-LymphocytesInfluenza A virusCytokinesImmunologic MemoryInterferon-gammaKi-67 AntigenCytokinesInterferon-gammaKi-67 AntigenCD4 T cellsCytokineImmune memoryInfluenza virusSurvival

Identifiers

PMID37490492
PMCPMC10947402
OpenAlexW4385251112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.