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Observational studyMycopathologia2023

Satellite Epidemic of Covid-19 Associated Mucormycosis in India: A Multi-Site Observational Study.

Aanchal Satija, Tanu Anand, Aparna Mukherjee, Poonam Sharma Velamuri, Kh Jitenkumar Singh, Madhuchhanda Das, Kripa Josten, Archana Y Keche, Nitin M Nagarkar, Prashant Gupta and 48 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Mycopathologia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Risk Factors forJournal of fungi (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

58 authors.

Aanchal Satija *Indian Council of Medical Research, New Delhi, India.
Tanu Anand *Indian Council of Medical Research, New Delhi, India.
Aparna MukherjeeIndian Council of Medical Research, New Delhi, India.
Poonam Sharma VelamuriIndian Council of Medical Research, New Delhi, India.
Kh Jitenkumar SinghNational Institute of Medical Statistics, New Delhi, India.
Madhuchhanda DasIndian Council of Medical Research, New Delhi, India.
Kripa JostenIndian Council of Medical Research, New Delhi, India.
Archana Y KecheAll India Institute of Medical Sciences, Raipur, India.
Nitin M NagarkarAll India Institute of Medical Sciences, Raipur, India.
Prashant GuptaKing George's Medical University, Lucknow, India.
D HimanshuKing George's Medical University, Lucknow, India.
Sejal N MistryPandit Deendayal Upadhyay Medical College, Rajkot, India.
Jimy D PatelPandit Deendayal Upadhyay Medical College, Rajkot, India.
Prajwal RaoDr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, India.
Shalesh RohatgiDr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, India.
Soumitra GhoshInstitute of Post Graduate Medical Education and Research, Kolkata, India.
Avijit HazraInstitute of Post Graduate Medical Education and Research, Kolkata, India.
Anupma Jyoti KindoSri Ramachandra Medical College and Research Institute, Chennai, India.
Radha AnnamalaiSri Ramachandra Medical College and Research Institute, Chennai, India.
Shivaprakash M RudramurthyPost Graduate Institute of Medical Education and Research, Chandigarh, India.
Mini P SinghPost Graduate Institute of Medical Education and Research, Chandigarh, India.
Mohammad ShameemJawaharlal Nehru Medical College Aligarh Muslim University, Aligarh, India.
Nazish FatimaJawaharlal Nehru Medical College Aligarh Muslim University, Aligarh, India.
Janakkumar R KhambholjaSmt. NHL Municipal Medical College, Ahmedabad, India.
Sangita ParikhAMC MET Medical College, Ahmedabad, India.
Manisha MadkaikarNational Institute of Immunohaematology (NIIH), Mumbai, India.
Vandana D PradhanNational Institute of Immunohaematology (NIIH), Mumbai, India.
Anudita BhargavaAll India Institute of Medical Sciences, Raipur, India.
Rupa MehataAll India Institute of Medical Sciences, Raipur, India.
Ripu Daman AroraAll India Institute of Medical Sciences, Raipur, India.
Richa TiggaAll India Institute of Medical Sciences, Raipur, India.
Gopa BanerjeeKing George's Medical University, Lucknow, India.
Vijay SonkarKing George's Medical University, Lucknow, India.
Hardeep Singh MalhotraKing George's Medical University, Lucknow, India.
Neeraj KumarKing George's Medical University, Lucknow, India.
Rajashri PatilDr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, India.
Chandrashekhar G RautDr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, India.
Kumkum BhattacharyyaInstitute of Post Graduate Medical Education and Research, Kolkata, India.
Preetam ArthurSri Ramachandra Medical College and Research Institute, Chennai, India.
L SomuSri Ramachandra Medical College and Research Institute, Chennai, India.
Padma SrikanthSri Ramachandra Medical College and Research Institute, Chennai, India.
Pankaj B ShahSri Ramachandra Medical College and Research Institute, Chennai, India.
Naresh K PandaPost Graduate Institute of Medical Education and Research, Chandigarh, India.
Dipti SharmaPost Graduate Institute of Medical Education and Research, Chandigarh, India.
Wasil HasanJawaharlal Nehru Medical College Aligarh Muslim University, Aligarh, India.
Aftab AhmedJawaharlal Nehru Medical College Aligarh Muslim University, Aligarh, India.
Meeta BathlaAMC MET Medical College, Ahmedabad, India.
Sunita SolankiAMC MET Medical College, Ahmedabad, India.
Hiren DoshiAMC MET Medical College, Ahmedabad, India.
Yash KananiSmt. NHL Municipal Medical College, Ahmedabad, India.
Nishi PatelAMC MET Medical College, Ahmedabad, India.
Zincal ShahAMC MET Medical College, Ahmedabad, India.
Alok Kumar TembhurneNational Institute of Immunohaematology (NIIH), Mumbai, India.
Chhaya RajguruGrant Government Medical College and Sir JJ Group of Hospitals, Mumbai, India.
Lalitkumar R SankheGrant Government Medical College and Sir JJ Group of Hospitals, Mumbai, India.
Shrinivas S ChavanGrant Government Medical College and Sir JJ Group of Hospitals, Mumbai, India.
Reetika Malik YadavNational Institute of Immunohaematology (NIIH), Mumbai, India.
Samiran PandaIndian Council of Medical Research, New Delhi, India. pandasamiran@gmail.com.ORCID http://orcid.org/0000-0002-5077-6275

Funding

Indian Council of Medical Research Mucormycosis/12/2021-ECD-II
6 · The paper itself

Abstract

backgroundSudden upsurge in cases of COVID-19 Associated Mucormycosis (CAM) following the second wave of the COVID-19 pandemic was recorded in India. This study describes the clinical characteristics, management and outcomes of CAM cases, and factors associated with mortality.

methodsMicrobiologically confirmed CAM cases were enrolled from April 2021 to September 2021 from ten diverse geographical locations in India. Data were collected using a structured questionnaire and entered into a web portal designed specifically for this investigation. Bivariate analyses and logistic regression were conducted using R version 4.0.2.

resultsA total of 336 CAM patients were enrolled; the majority were male (n = 232, 69.1%), literate (n = 261, 77.7%), and employed (n = 224, 66.7%). The commonest presenting symptoms in our cohort of patients were oro-facial and ophthalmological in nature. The median (Interquartile Range; IQR) interval between COVID diagnosis and admission due to mucormycosis was 31 (18, 47) days, whereas the median duration of symptoms of CAM before hospitalization was 10 (5, 20) days. All CAM cases received antifungal treatment, and debridement (either surgical or endoscopic or both) was carried out in the majority of them (326, 97.02%). Twenty-three (6.9%) of the enrolled CAM cases expired. The odds of death in CAM patients increased with an increase in HbA1c level (aOR: 1.34, 95%CI: 1.05, 1.72) following adjustment for age, gender, education and employment status.

conclusionA longer vigil of around 4-6 weeks post-COVID-19 diagnosis is suggested for earlier diagnosis of CAM. Better glycemic control may avert mortality in admitted CAM cases.

Indexed as

COVID-19MucormycosisCOVID-19 TestingFemaleHumansIndiaMalePandemicsDiabetes mellitusFungal infectionMortalityPandemicSARS-CoV 2Second wave

Identifiers

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.