Evidence map›Paper›PMID 37489991›Full record

ArticleRadiology2023

AI Body Composition in Lung Cancer Screening: Added Value Beyond Lung Cancer Detection.

Kaiwen Xu, Mirza S Khan, Thomas Z Li, Riqiang Gao, James G Terry, Yuankai Huo, Thomas A Lasko, John Jeffrey Carr, Fabien Maldonado, Bennett A Landman and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Risk prediction for lung cancer screening: a systematic review and meta-regression.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
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  6. When adipose meets inflammation: a novel adiposity-inflammation signature predicts prognosis and chemotherapy benefit in locally advanced gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Kaiwen XuFrom the Department of Computer Science (K.X., Y.H., T.A.L., B.A.L.), Department of Biomedical Engineering (T.Z.L., B.A.L.), School of Medicine (T.Z.L.), and Department of Electrical and Computer Engineering (Y.H., B.A.L.), Vanderbilt University, 2301 Vanderbilt Pl, Nashville, TN 37235; University of Missouri-Kansas City, Kansas City, Mo (M.S.K.); Saint Luke's Mid America Heart Institute, Kansas City, Mo (M.S.K.); Siemens Healthineers, Princeton, NJ (R.G.); Department of Radiology (J.G.T., J.J.C., B.A.L., K.L.S.), Department of Biomedical Informatics (T.A.L., J.J.C., B.A.L.), Division of Cardiovascular Medicine (J.J.C.), Division of Allergy, Pulmonary and Critical Care Medicine (F.M.), Vanderbilt University Institute of Imaging Science (B.A.L.), Vanderbilt Brain Institute (B.A.L.), Department of Psychiatry and Behavioral Sciences (B.A.L.), Department of Neurology (B.A.L.), and Vanderbilt Memory & Alzheimer's Center (B.A.L.), Vanderbilt University Medical Center, Nashville, Tenn.ORCID 0000-0002-2664-255X
Mirza S KhanFrom the Department of Computer Science (K.X., Y.H., T.A.L., B.A.L.), Department of Biomedical Engineering (T.Z.L., B.A.L.), School of Medicine (T.Z.L.), and Department of Electrical and Computer Engineering (Y.H., B.A.L.), Vanderbilt University, 2301 Vanderbilt Pl, Nashville, TN 37235; University of Missouri-Kansas City, Kansas City, Mo (M.S.K.); Saint Luke's Mid America Heart Institute, Kansas City, Mo (M.S.K.); Siemens Healthineers, Princeton, NJ (R.G.); Department of Radiology (J.G.T., J.J.C., B.A.L., K.L.S.), Department of Biomedical Informatics (T.A.L., J.J.C., B.A.L.), Division of Cardiovascular Medicine (J.J.C.), Division of Allergy, Pulmonary and Critical Care Medicine (F.M.), Vanderbilt University Institute of Imaging Science (B.A.L.), Vanderbilt Brain Institute (B.A.L.), Department of Psychiatry and Behavioral Sciences (B.A.L.), Department of Neurology (B.A.L.), and Vanderbilt Memory & Alzheimer's Center (B.A.L.), Vanderbilt University Medical Center, Nashville, Tenn.
Thomas Z LiFrom the Department of Computer Science (K.X., Y.H., T.A.L., B.A.L.), Department of Biomedical Engineering (T.Z.L., B.A.L.), School of Medicine (T.Z.L.), and Department of Electrical and Computer Engineering (Y.H., B.A.L.), Vanderbilt University, 2301 Vanderbilt Pl, Nashville, TN 37235; University of Missouri-Kansas City, Kansas City, Mo (M.S.K.); Saint Luke's Mid America Heart Institute, Kansas City, Mo (M.S.K.); Siemens Healthineers, Princeton, NJ (R.G.); Department of Radiology (J.G.T., J.J.C., B.A.L., K.L.S.), Department of Biomedical Informatics (T.A.L., J.J.C., B.A.L.), Division of Cardiovascular Medicine (J.J.C.), Division of Allergy, Pulmonary and Critical Care Medicine (F.M.), Vanderbilt University Institute of Imaging Science (B.A.L.), Vanderbilt Brain Institute (B.A.L.), Department of Psychiatry and Behavioral Sciences (B.A.L.), Department of Neurology (B.A.L.), and Vanderbilt Memory & Alzheimer's Center (B.A.L.), Vanderbilt University Medical Center, Nashville, Tenn.ORCID 0000-0001-9950-4679
Riqiang GaoFrom the Department of Computer Science (K.X., Y.H., T.A.L., B.A.L.), Department of Biomedical Engineering (T.Z.L., B.A.L.), School of Medicine (T.Z.L.), and Department of Electrical and Computer Engineering (Y.H., B.A.L.), Vanderbilt University, 2301 Vanderbilt Pl, Nashville, TN 37235; University of Missouri-Kansas City, Kansas City, Mo (M.S.K.); Saint Luke's Mid America Heart Institute, Kansas City, Mo (M.S.K.); Siemens Healthineers, Princeton, NJ (R.G.); Department of Radiology (J.G.T., J.J.C., B.A.L., K.L.S.), Department of Biomedical Informatics (T.A.L., J.J.C., B.A.L.), Division of Cardiovascular Medicine (J.J.C.), Division of Allergy, Pulmonary and Critical Care Medicine (F.M.), Vanderbilt University Institute of Imaging Science (B.A.L.), Vanderbilt Brain Institute (B.A.L.), Department of Psychiatry and Behavioral Sciences (B.A.L.), Department of Neurology (B.A.L.), and Vanderbilt Memory & Alzheimer's Center (B.A.L.), Vanderbilt University Medical Center, Nashville, Tenn.ORCID 0000-0002-8729-1941
James G TerryFrom the Department of Computer Science (K.X., Y.H., T.A.L., B.A.L.), Department of Biomedical Engineering (T.Z.L., B.A.L.), School of Medicine (T.Z.L.), and Department of Electrical and Computer Engineering (Y.H., B.A.L.), Vanderbilt University, 2301 Vanderbilt Pl, Nashville, TN 37235; University of Missouri-Kansas City, Kansas City, Mo (M.S.K.); Saint Luke's Mid America Heart Institute, Kansas City, Mo (M.S.K.); Siemens Healthineers, Princeton, NJ (R.G.); Department of Radiology (J.G.T., J.J.C., B.A.L., K.L.S.), Department of Biomedical Informatics (T.A.L., J.J.C., B.A.L.), Division of Cardiovascular Medicine (J.J.C.), Division of Allergy, Pulmonary and Critical Care Medicine (F.M.), Vanderbilt University Institute of Imaging Science (B.A.L.), Vanderbilt Brain Institute (B.A.L.), Department of Psychiatry and Behavioral Sciences (B.A.L.), Department of Neurology (B.A.L.), and Vanderbilt Memory & Alzheimer's Center (B.A.L.), Vanderbilt University Medical Center, Nashville, Tenn.ORCID 0000-0001-6659-3441
Yuankai HuoFrom the Department of Computer Science (K.X., Y.H., T.A.L., B.A.L.), Department of Biomedical Engineering (T.Z.L., B.A.L.), School of Medicine (T.Z.L.), and Department of Electrical and Computer Engineering (Y.H., B.A.L.), Vanderbilt University, 2301 Vanderbilt Pl, Nashville, TN 37235; University of Missouri-Kansas City, Kansas City, Mo (M.S.K.); Saint Luke's Mid America Heart Institute, Kansas City, Mo (M.S.K.); Siemens Healthineers, Princeton, NJ (R.G.); Department of Radiology (J.G.T., J.J.C., B.A.L., K.L.S.), Department of Biomedical Informatics (T.A.L., J.J.C., B.A.L.), Division of Cardiovascular Medicine (J.J.C.), Division of Allergy, Pulmonary and Critical Care Medicine (F.M.), Vanderbilt University Institute of Imaging Science (B.A.L.), Vanderbilt Brain Institute (B.A.L.), Department of Psychiatry and Behavioral Sciences (B.A.L.), Department of Neurology (B.A.L.), and Vanderbilt Memory & Alzheimer's Center (B.A.L.), Vanderbilt University Medical Center, Nashville, Tenn.ORCID 0000-0002-2096-8065
Thomas A LaskoFrom the Department of Computer Science (K.X., Y.H., T.A.L., B.A.L.), Department of Biomedical Engineering (T.Z.L., B.A.L.), School of Medicine (T.Z.L.), and Department of Electrical and Computer Engineering (Y.H., B.A.L.), Vanderbilt University, 2301 Vanderbilt Pl, Nashville, TN 37235; University of Missouri-Kansas City, Kansas City, Mo (M.S.K.); Saint Luke's Mid America Heart Institute, Kansas City, Mo (M.S.K.); Siemens Healthineers, Princeton, NJ (R.G.); Department of Radiology (J.G.T., J.J.C., B.A.L., K.L.S.), Department of Biomedical Informatics (T.A.L., J.J.C., B.A.L.), Division of Cardiovascular Medicine (J.J.C.), Division of Allergy, Pulmonary and Critical Care Medicine (F.M.), Vanderbilt University Institute of Imaging Science (B.A.L.), Vanderbilt Brain Institute (B.A.L.), Department of Psychiatry and Behavioral Sciences (B.A.L.), Department of Neurology (B.A.L.), and Vanderbilt Memory & Alzheimer's Center (B.A.L.), Vanderbilt University Medical Center, Nashville, Tenn.ORCID 0000-0003-2300-9529
John Jeffrey CarrFrom the Department of Computer Science (K.X., Y.H., T.A.L., B.A.L.), Department of Biomedical Engineering (T.Z.L., B.A.L.), School of Medicine (T.Z.L.), and Department of Electrical and Computer Engineering (Y.H., B.A.L.), Vanderbilt University, 2301 Vanderbilt Pl, Nashville, TN 37235; University of Missouri-Kansas City, Kansas City, Mo (M.S.K.); Saint Luke's Mid America Heart Institute, Kansas City, Mo (M.S.K.); Siemens Healthineers, Princeton, NJ (R.G.); Department of Radiology (J.G.T., J.J.C., B.A.L., K.L.S.), Department of Biomedical Informatics (T.A.L., J.J.C., B.A.L.), Division of Cardiovascular Medicine (J.J.C.), Division of Allergy, Pulmonary and Critical Care Medicine (F.M.), Vanderbilt University Institute of Imaging Science (B.A.L.), Vanderbilt Brain Institute (B.A.L.), Department of Psychiatry and Behavioral Sciences (B.A.L.), Department of Neurology (B.A.L.), and Vanderbilt Memory & Alzheimer's Center (B.A.L.), Vanderbilt University Medical Center, Nashville, Tenn.ORCID 0000-0002-4398-8237
Fabien MaldonadoFrom the Department of Computer Science (K.X., Y.H., T.A.L., B.A.L.), Department of Biomedical Engineering (T.Z.L., B.A.L.), School of Medicine (T.Z.L.), and Department of Electrical and Computer Engineering (Y.H., B.A.L.), Vanderbilt University, 2301 Vanderbilt Pl, Nashville, TN 37235; University of Missouri-Kansas City, Kansas City, Mo (M.S.K.); Saint Luke's Mid America Heart Institute, Kansas City, Mo (M.S.K.); Siemens Healthineers, Princeton, NJ (R.G.); Department of Radiology (J.G.T., J.J.C., B.A.L., K.L.S.), Department of Biomedical Informatics (T.A.L., J.J.C., B.A.L.), Division of Cardiovascular Medicine (J.J.C.), Division of Allergy, Pulmonary and Critical Care Medicine (F.M.), Vanderbilt University Institute of Imaging Science (B.A.L.), Vanderbilt Brain Institute (B.A.L.), Department of Psychiatry and Behavioral Sciences (B.A.L.), Department of Neurology (B.A.L.), and Vanderbilt Memory & Alzheimer's Center (B.A.L.), Vanderbilt University Medical Center, Nashville, Tenn.ORCID 0000-0002-6504-2063
Bennett A LandmanFrom the Department of Computer Science (K.X., Y.H., T.A.L., B.A.L.), Department of Biomedical Engineering (T.Z.L., B.A.L.), School of Medicine (T.Z.L.), and Department of Electrical and Computer Engineering (Y.H., B.A.L.), Vanderbilt University, 2301 Vanderbilt Pl, Nashville, TN 37235; University of Missouri-Kansas City, Kansas City, Mo (M.S.K.); Saint Luke's Mid America Heart Institute, Kansas City, Mo (M.S.K.); Siemens Healthineers, Princeton, NJ (R.G.); Department of Radiology (J.G.T., J.J.C., B.A.L., K.L.S.), Department of Biomedical Informatics (T.A.L., J.J.C., B.A.L.), Division of Cardiovascular Medicine (J.J.C.), Division of Allergy, Pulmonary and Critical Care Medicine (F.M.), Vanderbilt University Institute of Imaging Science (B.A.L.), Vanderbilt Brain Institute (B.A.L.), Department of Psychiatry and Behavioral Sciences (B.A.L.), Department of Neurology (B.A.L.), and Vanderbilt Memory & Alzheimer's Center (B.A.L.), Vanderbilt University Medical Center, Nashville, Tenn.ORCID 0000-0001-5733-2127
Kim L SandlerFrom the Department of Computer Science (K.X., Y.H., T.A.L., B.A.L.), Department of Biomedical Engineering (T.Z.L., B.A.L.), School of Medicine (T.Z.L.), and Department of Electrical and Computer Engineering (Y.H., B.A.L.), Vanderbilt University, 2301 Vanderbilt Pl, Nashville, TN 37235; University of Missouri-Kansas City, Kansas City, Mo (M.S.K.); Saint Luke's Mid America Heart Institute, Kansas City, Mo (M.S.K.); Siemens Healthineers, Princeton, NJ (R.G.); Department of Radiology (J.G.T., J.J.C., B.A.L., K.L.S.), Department of Biomedical Informatics (T.A.L., J.J.C., B.A.L.), Division of Cardiovascular Medicine (J.J.C.), Division of Allergy, Pulmonary and Critical Care Medicine (F.M.), Vanderbilt University Institute of Imaging Science (B.A.L.), Vanderbilt Brain Institute (B.A.L.), Department of Psychiatry and Behavioral Sciences (B.A.L.), Department of Neurology (B.A.L.), and Vanderbilt Memory & Alzheimer's Center (B.A.L.), Vanderbilt University Medical Center, Nashville, Tenn.ORCID 0000-0003-2989-248X
Vanderbilt University · US

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Validation of Biomarkers of Risk for the Early Detection of Lung CancerU01CA152662 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DEPPEN, STEPHEN, GROGAN, ERIC L · 2010 to 2025
$12.8M
Cellular, molecular and quantitative imaging analysis of screening-detected lung adenocarcinomaU01CA196405 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MALDONADO, FABIEN · 2015 to 2020
$5.4M
Controlling Quality and Capturing Uncertainty in Advanced Diffusion Weighted MRIR01EB017230 · NIBIB · VANDERBILT UNIVERSITY · PI LANDMAN, BENNETT A. · 2015 to 2024
$5.1M
CARDIOVASCULAR OUTCOMES RESEARCH TRAINING PROGRAMT32HL110837 · NHLBI · UNIVERSITY OF MISSOURI KANSAS CITY · PI JOHN A SPERTUS · 2012 to 2026
$5.0M
Novel Integrative Approach for the Early Detection of Lung Cancer using Repeated MeasuresR01CA253923 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LANDMAN, BENNETT A., MALDONADO, FABIEN · 2021 to 2025
$3.4M
NCATS NIH HHS UL1 TR000445NCI NIH HHS R01 CA253923NCI NIH HHS U01 CA152662NCI NIH HHS U01 CA196405NCRR NIH HHS UL1 RR024975NHLBI NIH HHS T32 HL110837NIBIB NIH HHS R01 EB017230
6 · The paper itself

Abstract

Background An artificial intelligence (AI) algorithm has been developed for fully automated body composition assessment of lung cancer screening noncontrast low-dose CT of the chest (LDCT) scans, but the utility of these measurements in disease risk prediction models has not been assessed. Purpose To evaluate the added value of CT-based AI-derived body composition measurements in risk prediction of lung cancer incidence, lung cancer death, cardiovascular disease (CVD) death, and all-cause mortality in the National Lung Screening Trial (NLST). Materials and Methods In this secondary analysis of the NLST, body composition measurements, including area and attenuation attributes of skeletal muscle and subcutaneous adipose tissue, were derived from baseline LDCT examinations by using a previously developed AI algorithm. The added value of these measurements was assessed with sex- and cause-specific Cox proportional hazards models with and without the AI-derived body composition measurements for predicting lung cancer incidence, lung cancer death, CVD death, and all-cause mortality. Models were adjusted for confounding variables including age; body mass index; quantitative emphysema; coronary artery calcification; history of diabetes, heart disease, hypertension, and stroke; and other PLCO

Indexed as

Cardiovascular DiseasesLung NeoplasmsArtificial IntelligenceBody CompositionEarly Detection of CancerFemaleHumansLungMaleMiddle Aged

Identifiers

PMID37489991
PMCPMC10374937
OpenAlexW4385230439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.