Evidence map›Paper›PMID 37489900›Full record

ArticlemBio2023

Global analysis of putative phospholipases in

Paul-Christian Burda, Abhinay Ramaprasad, Sabrina Bielfeld, Emma Pietsch, Anna Woitalla, Christoph Söhnchen, Mehar Nihal Singh, Jan Strauss, Aaron Sait, Lucy M Collinson and 3 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Functional analysis of CaParasitology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. The patatin-like phospholipaseFrontiers in cellular and infection microbiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Paul-Christian Burda *Centre for Structural Systems Biology , Hamburg, Germany.ORCID 0000-0003-0461-4352
Abhinay Ramaprasad *Malaria Biochemistry Laboratory, The Francis Crick Institute , London, United Kingdom.ORCID 0000-0001-9372-5526
Sabrina BielfeldCentre for Structural Systems Biology , Hamburg, Germany.
Emma PietschCentre for Structural Systems Biology , Hamburg, Germany.ORCID 0000-0003-4744-1666
Anna WoitallaDivision of Bioanalytical Chemistry, Research Center Borstel, Leibniz Lung Center , Borstel, Germany.
Christoph SöhnchenCentre for Structural Systems Biology , Hamburg, Germany.
Mehar Nihal SinghMalaria Biochemistry Laboratory, The Francis Crick Institute , London, United Kingdom.
Jan StraussCentre for Structural Systems Biology , Hamburg, Germany.ORCID 0000-0002-6208-791X
Aaron SaitElectron Microscopy Science Technology Platform, The Francis Crick Institute , London, United Kingdom.
Lucy M CollinsonElectron Microscopy Science Technology Platform, The Francis Crick Institute , London, United Kingdom.ORCID 0000-0003-0260-613X
Dominik SchwudkeDivision of Bioanalytical Chemistry, Research Center Borstel, Leibniz Lung Center , Borstel, Germany.ORCID 0000-0002-1379-9451
Michael J BlackmanMalaria Biochemistry Laboratory, The Francis Crick Institute , London, United Kingdom.ORCID 0000-0002-7442-3810
Tim-Wolf GilbergerCentre for Structural Systems Biology , Hamburg, Germany.ORCID 0000-0002-7965-8272
Universität Hamburg · DEThe Francis Crick Institute · GBGerman Center for Infection Research · DEResearch Center Borstel - Leibniz Lung Center · DE

Funding

Cancer Research UKMedical Research CouncilWellcome Trust FC001043
6 · The paper itself

Abstract

For its replication within red blood cells, the malaria parasite depends on a highly active and regulated lipid metabolism. Enzymes involved in lipid metabolic processes such as phospholipases are, therefore, potential drug targets. Here, using reverse genetics approaches, we show that only 1 out of the 19 putative phospholipases expressed in asexual blood stages of

Indexed as

MalariaMalaria, FalciparumParasitesAnimalsErythrocytesHumansPhosphatidylinositolsPhosphoinositide Phospholipase CPhospholipasesPhospholipidsPlasmodium falciparumProtozoan ProteinsPhosphatidylinositolsPhosphoinositide Phospholipase CPhospholipasesPhospholipidsProtozoan Proteinsblood stagemalariaphosphoinositidesphospholipase

Identifiers

PMID37489900
PMCPMC10470789
OpenAlexW4385231210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.