Evidence map›Paper›PMID 37489832›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2023

Chromatin architectural factor CTCF is essential for progesterone-dependent uterine maturation.

Sylvia C Hewitt, Artiom Gruzdev, Cynthia J Willson, San-Pin Wu, John P Lydon, Niels Galjart, Francesco J DeMayo

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Sylvia C HewittPregnancy & Female Reproduction, DIR RDBL, NIEHS, Research Triangle Park, North Carolina, USA.ORCID https://orcid.org/0000-0001-7713-0805
Artiom GruzdevKnockout Mouse Core Facility, DIR RDBL, NIEHS, Research Triangle Park, North Carolina, USA.ORCID https://orcid.org/0000-0002-1698-7159
Cynthia J WillsonInotiv-RTP, Research Triangle Park, North Carolina, USA.ORCID https://orcid.org/0000-0003-0942-3723
San-Pin WuPregnancy & Female Reproduction, DIR RDBL, NIEHS, Research Triangle Park, North Carolina, USA.ORCID https://orcid.org/0000-0001-9626-784X
John P LydonBaylor College of Medicine, Houston, Texas, USA.ORCID https://orcid.org/0000-0001-6472-636X
Niels GaljartDepartment of Cell Biology, Erasmus MC, Rotterdam, Netherlands.ORCID https://orcid.org/0000-0003-1964-3607
Francesco J DeMayoPregnancy & Female Reproduction, DIR RDBL, NIEHS, Research Triangle Park, North Carolina, USA.ORCID https://orcid.org/0000-0002-9480-7336
Research Triangle Park Foundation · USBaylor College of Medicine · USErasmus MC · NL

Funding

Environmental Signaling in Reproduction and PregnancyZIAES103311 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI DEMAYO, FRANCESCO · 2016 to 2025
$30.5M
REPRODUCTIVE HORMONES: BIOLOGICAL AND MOLECULAR ACTIONSR01HD008188 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI DAVID M LONARD, JOHN P LYDON · 1985 to 2026
$16.3M
SEX HORMONE RECEPTOR COMPONENTS AND THE CELL GENOMER01HD007857 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI DAVID M LONARD, JOHN P LYDON · 1985 to 2026
$14.6M
Molecular Analysis of Uterine ReceptivityR01HD042311 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI LYDON, JOHN P · 2009 to 2023
$4.8M
Intramural NIH HHS ZIA ES103311NICHD NIH HHS R01 HD007857NICHD NIH HHS R01 HD008188NICHD NIH HHS R01 HD042311
6 · The paper itself

Abstract

Receptors for estrogen and progesterone frequently interact, via Cohesin/CTCF loop extrusion, at enhancers distal from regulated genes. Loss-of-function CTCF mutation in >20% of human endometrial tumors indicates its importance in uterine homeostasis. To better understand how CTCF-mediated enhancer-gene interactions impact endometrial development and function, the Ctcf gene was selectively deleted in female reproductive tissues of mice. Prepubertal Ctcf

Indexed as

ChromatinEndometrial NeoplasmsAnimalsEndometriumFemaleHumansMiceProgesteroneUterusChromatinProgesteronechromatinestrogenprogesteronepubertyuterus

Identifiers

PMID37489832
PMCPMC10372848
OpenAlexW4385230610

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.