Evidence map›Paper›PMID 37489376›Full record

ArticleHematology reports2023

Safe and Effective Administration of Caplacizumab in COVID-19-Associated Thrombotic Thrombocytopenic Purpura.

Antonella Bruzzese, Ernesto Vigna, Dario Terzi, Sonia Greco, Enrica Antonia Martino, Valeria Vangeli, Francesco Mendicino, Eugenio Lucia, Virginia Olivito, Caterina Labanca and 6 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Hematology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Antonella BruzzeseHematology Unit, Azienda Ospedaliera Annunziata, 87100 Cosenza, Italy.
Ernesto VignaHematology Unit, Azienda Ospedaliera Annunziata, 87100 Cosenza, Italy.
Dario TerziImmunohaematology Section, Annunziata Hospital, 87100 Cosenza, Italy.
Sonia GrecoInfectious & Tropical Diseases Unit, Annunziata Hospital, 87100 Cosenza, Italy.
Enrica Antonia MartinoHematology Unit, Azienda Ospedaliera Annunziata, 87100 Cosenza, Italy.
Valeria VangeliInfectious & Tropical Diseases Unit, Annunziata Hospital, 87100 Cosenza, Italy.
Francesco MendicinoHematology Unit, Azienda Ospedaliera Annunziata, 87100 Cosenza, Italy.ORCID 0000-0001-6339-632X
Eugenio LuciaHematology Unit, Azienda Ospedaliera Annunziata, 87100 Cosenza, Italy.
Virginia OlivitoHematology Unit, Azienda Ospedaliera Annunziata, 87100 Cosenza, Italy.
Caterina LabancaHematology Unit, Azienda Ospedaliera Annunziata, 87100 Cosenza, Italy.
Rosellina MorelliMedicine Department, "Annunziata" Hospital of Cosenza, 87100 Cosenza, Italy.
Antonino NeriScientific Directorate IRCCS of Reggio Emilia, 42123 Reggio Emilia, Italy.
Fortunato MorabitoBiotechnology Research Unit, AO of Cosenza, 87100 Cosenza, Italy.ORCID 0000-0002-2585-7073
Francesco ZinnoImmunohaematology Section, Annunziata Hospital, 87100 Cosenza, Italy.
Antonio MastroianniInfectious & Tropical Diseases Unit, Annunziata Hospital, 87100 Cosenza, Italy.
Massimo GentileHematology Unit, Azienda Ospedaliera Annunziata, 87100 Cosenza, Italy.
Ospedale Annunziata di Cosenza · ITAzienda Ospedaliera di Cosenza · ITAzienda Sanitaria Unità Locale di Reggio Emilia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thrombotic thrombocytopenic purpura (TTP) is a potentially life-threatening, rare acute thrombotic microangiopathy (TMA), caused by a severe ADAMTS13 deficiency. As the COVID-19 pandemic rapidly spread around the globe, much data about the pathogenicity of this virus were published. Soon after the detection of the first cases of COVID-19, it was clear that there was a wide range of COVID coagulopathy manifestations, such as deep venous thrombosis, pulmonary thromboembolism, and thrombotic microangiopathies. In the literature, little data have been reported about the association between TTP and COVID-19, and the treatment of COVID-19-associated TTP is still under debate. Here we present the case of a 46-year-old woman who developed a COVID-associated TTP, successfully treated with plasma exchange (PEX), steroids, and caplacizumab.

Indexed as

caplacizumabCOVID-19TTP

Identifiers

PMID37489376
PMCPMC10366750
OpenAlexW4385066669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.