Evidence map›Paper›PMID 37489330›Full record

ArticleJournal of developmental biology2023

The Tumor Suppressor

Xiaolei Liu, William D Jones, Mathieu Quesnel-Vallières, Sudhish A Devadiga, Kristin Lorent, Alexander J Valvezan, Rebecca L Myers, Ning Li, Christopher J Lengner, Yoseph Barash and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of developmental biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Xiaolei LiuDepartment of Medicine (Hematology-Oncology), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
William D JonesCell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-5568-3035
Mathieu Quesnel-VallièresDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sudhish A DevadigaFaculty of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0009-0002-3252-3458
Kristin LorentDepartment of Medicine (Gastroenterology), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Alexander J ValvezanDepartment of Medicine (Hematology-Oncology), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Rebecca L MyersDepartment of Medicine (Hematology-Oncology), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ning LiDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-5997-5556
Christopher J LengnerDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yoseph BarashDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Michael PackDepartment of Medicine (Gastroenterology), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Peter S KleinDepartment of Medicine (Hematology-Oncology), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-2011-8538
University of Pennsylvania · USCalifornia Institute for Regenerative Medicine · US

Funding

Cassette exons in neoplastic pro-B-cells: implications for immunotherapyU01CA232563 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI BARASH, YOSEPH, THOMAS-TIKHONENKO, ANDREI · 2018 to 2022
$3.5M
An unexpected signaling output for the tumor suppressor APCR01GM115517 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KLEIN, PETER S · 2016 to 2019
$1.3M
Targeting splicing in myelodysplasia through GSK-3R56DK133258 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI KLEIN, PETER S · 2022 to 2022
$100k
NCI NIH HHS U01 CA232563NIDDK NIH HHS R56 DK133258NIGMS NIH HHS R01 GM115517NIH HHS R01GM115517NIH HHS R56DK133258NIH HHS U01CA232563
6 · The paper itself

Abstract

Neural crest (NC) is a unique vertebrate cell type arising from the border of the neural plate and epidermis that gives rise to diverse tissues along the entire body axis. Roberto Mayor and colleagues have made major contributions to our understanding of NC induction, delamination, and migration. We report that a truncating mutation of the classical tumor suppressor

Indexed as

APCcolon cancercomplement C3cranial neural crestcraniofacialEMTGSK-3mTORpharyngeal archsplicingWnt

Identifiers

PMID37489330
PMCPMC10366761
OpenAlexW4382789967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.