Evidence map›Paper›PMID 37489285›Full record

ArticlePediatrics2023

Failure to Complete Multidose Vaccine Series in Early Childhood.

Sarah Y Michels, Linda M Niccolai, James L Hadler, Rain E Freeman, Alexandria N Albers, Jason M Glanz, Matthew F Daley, Sophia R Newcomer

Open access · bronzeAbstract read
In one paragraph

Article in Pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sarah Y MichelsYale School of Public Health, New Haven, Connecticut.
Linda M NiccolaiYale School of Public Health, New Haven, Connecticut.
James L HadlerYale School of Public Health, New Haven, Connecticut.
Rain E FreemanCenter for Population Health Research, University of Montana, Missoula, Montana.
Alexandria N AlbersCenter for Population Health Research, University of Montana, Missoula, Montana.
Jason M GlanzInstitute for Health Research, Kaiser Permanente Colorado, Aurora, Colorado.
Matthew F DaleyInstitute for Health Research, Kaiser Permanente Colorado, Aurora, Colorado.
Sophia R NewcomerCenter for Population Health Research, University of Montana, Missoula, Montana.
University of Montana · USYale New Haven Health System · USKaiser Permanente · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Wildfires and Cardiovascular Health: Evaluating Associations and Intervention StrategiesP20GM130418 · NIGMS · UNIVERSITY OF MONTANA · PI Maja Pedersen · 2020 to 2026
$17.9M
Population-level assessment of early childhood vaccination timeliness, parental vaccine hesitancy, and immunization schedule adherence in the United States, including rural-urban disparitiesR01AI165768 · NIAID · UNIVERSITY OF MONTANA · PI NEWCOMER, SOPHIA RAFF · 2021 to 2024
$1.6M
NCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI165768NIGMS NIH HHS P20 GM130418
6 · The paper itself

Abstract

backgroundMost early childhood immunizations require 3 to 4 doses to achieve optimal protection. Our objective was to identify factors associated with starting but not completing multidose vaccine series.

methodsUsing 2019 National Immunization Survey-Child data, US children ages 19 to 35 months were classified in 1 of 3 vaccination patterns: (1) completed the combined 7-vaccine series, (2) did not initiate ≥1 of the 7 vaccine series, or (3) initiated all series, but did not complete ≥1 multidose series. Associations between sociodemographic factors and vaccination pattern were evaluated using multivariable log-linked binomial regression. Analyses accounted for the survey's stratified design and complex weighting.

resultsAmong 16 365 children, 72.9% completed the combined 7-vaccine series, 9.9% did not initiate ≥1 series, and 17.2% initiated, but did not complete ≥1 multidose series. Approximately 8.4% of children needed only 1 additional vaccine dose from 1 of the 5 multidose series to complete the combined 7-vaccine series. The strongest associations with starting but not completing multidose vaccine series were moving across state lines (adjusted prevalence ratio [aPR] = 1.45, 95% confidence interval [CI]: 1.18-1.79), number of children in the household (2 to 3: aPR = 1.29, 95% CI: 1.05-1.58; 4 or more: aPR = 1.68, 95% CI: 1.30-2.18), and lack of insurance coverage (aPR = 2.03, 95% CI: 1.42-2.91).

conclusionsMore than 1 in 6 US children initiated but did not complete all doses in multidose vaccine series, suggesting children experienced structural barriers to vaccination. Increased focus on strategies to encourage multidose series completion is needed to optimize protection from preventable diseases and achieve vaccination coverage goals.

Indexed as

VaccinationVaccinesChild, PreschoolFamily CharacteristicsHumansInfantVaccination CoverageVaccines

Identifiers

PMID37489285
PMCPMC10389773
OpenAlexW4385230985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.